Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24445987 | 0.81 | HPGD (0.46) | CYP4F2CYP4A11ALDH1A1GAASLC7A5 | |
| SCHEMBL10029758 | 0.80 | CAPN1 (0.42) | CAPN1ALDH1A1SLC7A5SMN1; SMN2NPC1 | |
| SCHEMBL8225225 | 0.78 | — | — | |
| SCHEMBL4113212 | 0.77 | CYP4F2 (0.76) | CYP4F2CYP4A11HSP90AB1ALDH1A1GAA | |
| SCHEMBL4010965 | 0.76 | SLC7A5 (0.47) | CYP4F2CYP4A11HSP90AB1ALDH1A1GAA | |
| SCHEMBL311759 | 0.75 | — | — | |
| SCHEMBL28124618 | 0.74 | CAPN1 (0.47) | CAPN1ALDH1A1KMT2ATRPM8 | |
| SCHEMBL24612546 | 0.74 | ICMT (0.45) | CYP4F2CYP4A11ALDH1A1GAAGFER | |
| SCHEMBL5739617 | 0.74 | CYP4F2 (0.51) | CYP4F2CYP4A11HSP90AB1ALDH1A1GAA | |
| SCHEMBL11676891 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9877947-B2 | C-terminal HSP90 inhibitors to treat pituitary adenomas | Max-Planck-Gesellschaft zur Föderung der Wissenschaften E.V. (DE) | 2018-01-30 | — | — | US | disclosed |
| US-20110190461-A1 | NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER | NAGASE CHEMTEX CORPORATION (JP) | 2011-08-04 | — | — | US | disclosed |
| EP-2086958-A2 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | Purdue Pharma LP (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2009027820-A2 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. (DE) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190461-A1 | NOVEL HETEROCYCLIC AROMATIC COMPOUND AND POLYMER | PAH, AHR, KCNH3 | CYP4F2 195/4885CYP4A11 426/4885HSP90AB1 1601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.