Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 11/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 6/20 | 0.61 |
| ▸ | DRD3 | P35462 | 5/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HTR2B | P41595 | 3/20 | 0.61 |
| ▸ | HRH1 | P35367 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27921604 | 0.91 | HTR7 (0.62) | HTR7HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4225899 | 0.91 | HTR7 (0.62) | HTR7HDAC3HDAC1HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL4224101 | 0.90 | HTR7 (0.61) | HTR7HDAC3HDAC1HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL4231322 | 0.90 | HTR7 (0.61) | HTR7HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4229926 | 0.90 | HTR7 (0.64) | HTR7HDAC3HDAC1HDAC2HDAC8 | |
| Fumaric Acid SCHEMBL4232356 | 0.89 | HTR7 (0.62) | HTR7HDAC3HDAC1HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL4224319 | 0.88 | HTR7 (0.62) | HTR7HDAC3HDAC1HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL4222983 | 0.88 | HTR7 (0.62) | HTR7HDAC3HDAC1HDAC2HDAC8 | |
| Oxalic Acid SCHEMBL4228870 | 0.88 | HDAC3 (0.68) | HTR7HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2795026 | 0.85 | HTR7 (0.63) | HTR7HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-7211585-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-01 | — | — | US | disclosed |
| US-20060040978-A1 | 5-HT7 receptor antagonists | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163542-A1 | 5-ht7 receptor antagonists | HTR7, HTR1A, HTR5A | SLC6A4 20/4885HTR7 1/4885HDAC3 2350/4885 |
| US-20060040978-A1 | 5-HT7 receptor antagonists | HTR7, HTR1A, HTR5A | SLC6A4 20/4885HTR7 1/4885HDAC3 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.