Sugi Predict

Sugi Predict / Compounds / Glutamic Acid

Glutamic Acid

Glutamic Acid

SCHEMBL4229342

N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](COC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 2/20 0.43
▸ GRM8 O00222 2/20 0.43
▸ GRM6 O15303 2/20 0.43
▸ GRM7 Q14831 2/20 0.43
▸ GRM4 Q14833 2/20 0.43
▸ GRIN2D O15399 1/20 0.43
▸ GRIN3B O60391 1/20 0.43
▸ GSR P00390 1/20 0.43
▸ GRIK1 P39086 1/20 0.43
▸ GRM5 P41594 1/20 0.43
▸ GRIA1 P42261 1/20 0.43
▸ GRIA2 P42262 1/20 0.43
▸ GRIA3 P42263 1/20 0.43
▸ SLC1A3 P43003 1/20 0.43
▸ SLC1A2 P43004 1/20 0.43
▸ SLC1A1 P43005 1/20 0.43
▸ GRIA4 P48058 1/20 0.43
▸ GRIN1 Q05586 1/20 0.43
▸ GRIN2A Q12879 1/20 0.43
▸ GRIK2 Q13002 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL874924 0.91 SLC1A5 (0.38) CYP1A2GRIK1GRIA1GRIA2GRIA3
Glycine SCHEMBL3967554 0.89 SLC1A5 (0.35) CYP1A2SLC1A5CYP3A4SLC7A5IDO1
Histidine SCHEMBL2228115 0.89 CYP1A2 (0.51) CYP1A2GRM8GRM6GRM7GRM4
Histidine SCHEMBL4356748 0.89 CYP1A2 (0.51) CYP1A2GRM8GRM6GRM7GRM4
Histidine SCHEMBL19209941 0.89 CYP1A2 (0.51) CYP1A2GRM8GRM6GRM7GRM4
Histidine SCHEMBL23306565 0.89 CYP1A2 (0.51) CYP1A2GRM8GRM6GRM7GRM4
Aspartic Acid SCHEMBL7582142 0.88 SLC1A5 (0.34) CYP1A2SLC1A5CYP3A4SLC7A5IDO1
Histidine SCHEMBL23291081 0.87 CYP1A2 (0.50) CYP1A2GRM8GRM6GRM7GRM4
Lysine SCHEMBL18297985 0.86 GSR (0.46) GSRSLC1A5ARG1LTA4H
Histidine SCHEMBL27926628 0.85 SLC7A5 (0.36) CYP1A2GRIK1GRIA1GRIA2GRIA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090291948-A1 SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE DECODE GENETICS EHF (IS) 2009-11-26 — — US disclosed
US-7598397-B2 Sulfonamide peri-substituted bicyclics for occlusive artery disease DECODE GENETICS EHF (IS) 2009-10-06 — — US disclosed
US-20060079520-A1 Sulfonamide peri-substituted bicyclics for occlusive artery disease SAGA INVESTMENTS LLC 2006-04-13 — — US disclosed
US-20040081998-A1 Novel carboxylesterase nucleic acid molecules, proteins and uses thereof SILVER GARY M (US) 2004-04-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060079520-A1 Sulfonamide peri-substituted bicyclics for occlusive artery disease PTGIS, PTGIR, PTGS2 CYP1A2 797/4885GRM8 1314/4885GRM6 2425/4885
US-20090291948-A1 SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE PTGIS, PTGIR, PTGS2 CYP1A2 797/4885GRM8 1314/4885GRM6 2425/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.