Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGCG | Q16739 | 14/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169484 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 | |
| Eliglustat SCHEMBL4057024 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 | |
| SCHEMBL4067738 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 | |
| SCHEMBL419334 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 | |
| Eliglustat SCHEMBL21648647 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 | |
| Eliglustat SCHEMBL21252721 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 | |
| SCHEMBL1085008 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 | |
| SCHEMBL12091633 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 | |
| Eliglustat SCHEMBL4058275 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 | |
| SCHEMBL761669 | 1.00 | UGCG (1.00) | UGCGHTR1APTGS1OPRM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190350913-A1 | INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES | ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) (FR) | 2019-11-21 | — | — | US | claimed |
| EP-3080602-B1 | TREATING NEURODEGENERATIVE DISEASE | BRIGHAM & WOMENS HOSPITAL INC (US) | 2018-11-28 | — | — | EP | claimed |
| EP-1811991-B1 | Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis | GENZYME CORP (US) | 2018-11-07 | — | — | EP | claimed |
| US-9927437-B2 | Treating neurodegenerative disease | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2018-03-27 | — | — | US | claimed |
| US-20170281593-A1 | Methods of Treating Fatty Liver Disease | GENZYME CORPORATION | 2017-10-05 | — | — | US | claimed |
| US-9556155-B2 | Methods of treating fatty liver disease | GENZYME CORPORATION (US) | 2017-01-31 | — | — | US | claimed |
| US-9532976-B2 | Method of lowering blood glucose | GENZYME CORPORATION (US) | 2017-01-03 | — | — | US | claimed |
| US-20160313324-A1 | TREATING NEURODEGENERATIVE DISEASE | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-10-27 | — | — | US | claimed |
| EP-3080602-A2 | TREATING NEURODEGENERATIVE DISEASE | The Brigham and Women's Hospital, Inc. (US) | 2016-10-19 | — | — | EP | claimed |
| EP-2923699-A1 | METHODS OF TREATING FATTY LIVER DISEASE | Genzyme Corporation (US) | 2015-09-30 | — | — | EP | claimed |
| US-20150051261-A1 | Methods of Treating Fatty Liver Disease | GENZYME CORPORATION (US) | 2015-02-19 | — | — | US | claimed |
| US-20120022126-A1 | Method Of Treating Diabetes Mellitus | GENZYME CORPORATION (US) | 2012-01-26 | — | — | US | claimed |
| US-8003617-B2 | e.g. 1-(3',4'-ethylenedioxy)phenyl-2-nonanoylamino-3-pyrrolidino-1-propanol; glucosylceramide synthase inhibitor; inhibits glycosphingolipid synthesis; antidiabetic, hypoglycemic agent; non-insulin dependent diabetes, obesity, Gaucher's disease | GENZYME CORPORATION (US) | 2011-08-23 | — | — | US | claimed |
| EP-2032134-A2 | METHODS OF TREATING FATTY LIVER DISEASE COMPRISING INHIBITING GLUCOSPHINGOLIPID SYNTHESIS | Genzyme Corporation (US) | 2009-03-11 | — | — | EP | claimed |
| EP-2010536-A1 | IMIDAZO [1, 2-B]PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS | Ferrer Internacional, S.A. (ES) | 2009-01-07 | — | — | EP | claimed |
| US-20080161379-A1 | Methods of Treating Diabetes Mellitus | GENZYME CORPORATION | 2008-07-03 | — | — | US | claimed |
| WO-2007134086-A2 | METHODS OF TREATING FATTY LIVER DISEASE COMPRISING INHIBITING GLUCOSPHINGOLIPID SYNTHESIS | GENZYME CORPORATION (US) | 2007-11-22 | — | — | WO | claimed |
| WO-2007110437-A1 | IMIDAZO [1, 2-B] PYRIDAZINES, THEIR PROCESSES OF PREPARATION AND THEIR USE AS GABA RECEPTOR LIGANDS | FERRER INTERNACIONAL, S.A. (ES) | 2007-10-04 | — | — | WO | claimed |
| EP-1811991-A2 | METHODS OF TREATING DIABETES MELLITUS | Genzyme Corporation (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006053043-A2 | METHODS OF TREATING DIABETES MELLITUS | GENZYME CORPORATION (US) | 2006-05-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051261-A1 | Methods of Treating Fatty Liver Disease | LIPC, GYS2, PNLIP | UGCG 7/4885HTR1A 3913/4885PTGS1 1157/4885 |
| US-20170281593-A1 | Methods of Treating Fatty Liver Disease | LIPC, GYS2, PNLIP | UGCG 7/4885HTR1A 3913/4885PTGS1 1157/4885 |
| US-20120022126-A1 | Method Of Treating Diabetes Mellitus | ASAH2, ASAH1, GBA1 | UGCG 4/4885HTR1A 3224/4885PTGS1 607/4885 |
| US-20190350913-A1 | INHIBITORS OF GANGLIOSIDES METABOLISM FOR THE TREATMENT OF MOTOR NEURON DISEASES | GBA1, SMN1; SMN2, GAA | UGCG 13/4885HTR1A 3677/4885PTGS1 1570/4885 |
| US-20080161379-A1 | Methods of Treating Diabetes Mellitus | ASAH2, PNLIP, ASAH1 | UGCG 4/4885HTR1A 3041/4885PTGS1 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.