⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11222069 | 0.97 | — | — | |
| SCHEMBL41856 | 0.83 | — | — | |
| SCHEMBL62340 | 0.81 | CA2 (0.86) | — | |
| Trifluoroacetic Acid SCHEMBL30556693 | 0.81 | CA1 (0.50) | — | |
| SCHEMBL4622863 | 0.79 | CA2 (0.82) | — | |
| SCHEMBL1668208 | 0.79 | CA2 (0.82) | — | |
| SCHEMBL1228645 | 0.79 | CA2 (0.82) | — | |
| SCHEMBL22435913 | 0.79 | CA1 (0.54) | — | |
| SCHEMBL80252 | 0.79 | CA2 (0.82) | — | |
| SCHEMBL3312980 | 0.79 | CA2 (0.82) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 292 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10669264-B2 | Process for the preparation of macitentan | LAURUS LABS LIMITED (IN) | 2020-06-02 | — | — | US | claimed |
| US-20180370954-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF MACITENTAN | Laurus Labs Ltd. (IN) | 2018-12-27 | — | — | US | claimed |
| WO-2017191565-A1 | PROCESS FOR PREPARATION OF MACITENTAN | SHILPA MEDICARE LIMITED (IN) | 2017-11-09 | — | — | WO | claimed |
| WO-2017093903-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF MACITENTAN | LAURUS LABS PRIVATE LIMITED (IN) | 2017-06-08 | — | — | WO | claimed |
| CN-104897833-B | A kind of detection method of ACT-064992 intermediate and its application | 成都克莱蒙医药科技有限公司 | 2017-03-01 | — | — | CN | claimed |
| CN-104897833-A | Detection method for macitentan intermediate and application thereof | CHENGDU CLIMB PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-09-09 | — | — | CN | claimed |
| EP-2488031-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | claimed |
| CN-119143680-A | Preparation method of macitentan impurity B | 河北科技大学 | 2024-12-17 | — | — | CN | disclosed |
| CN-119143680-A | Preparation method of macitentan impurity B | 河北科技大学 | 2024-12-17 | — | — | CN | disclosed |
| CN-118139529-A | Triazolinone herbicide and safener combination | UPL有限责任公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-117534630-A | Method for refining high-purity famotidine to prepare B crystal form | 重庆世森医药科技有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-116848091-A | Inhibitors of ectonucleotide pyrophosphatase-phosphodiesterase-1 (ENPP 1) and uses thereof | 1CBIO公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-112569210-B | Ma Xiteng tam solution for inhalation and preparation method thereof | 盈科瑞（天津）创新医药研究有限公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-0905202-A1 | PHOTOSTABILIZED CYANINE DYES AND OPTICAL RECORDING MEDIUM | TDK Corporation (JP) | 1999-03-31 | — | — | EP | disclosed |
| US-5879772-A | Information recording medium | FUJI PHOTO FILM CO., LTD. (JP) | 1999-03-09 | — | — | US | disclosed |
| EP-0820057-A1 | Information recording medium | FUJI PHOTO FILM CO., LTD. (JP) | 1998-01-21 | — | — | EP | disclosed |
| WO-1997047690-A1 | DYE MIXTURES | BASF AKTIENGESELLSCHAFT (DE) | 1997-12-18 | — | — | WO | disclosed |
| EP-0386669-A2 | Color light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1990-09-12 | — | — | EP | disclosed |
| EP-0319985-A2 | Color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-06-14 | — | — | EP | disclosed |