SCHEMBL423281

SCHEMBL423281

Cc1ccc2scc(C)c2c1

nearest known ligand 0.64

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.64
MAPT P10636 13/20 0.46
TP53 P04637 7/20 0.46
CA2 P00918 1/20 0.46
THRB P10828 2/20 0.45
USP2 O75604 2/20 0.45
LMNA P02545 1/20 0.42
CYP1A2 P05177 2/20 0.39
POLB P06746 1/20 0.35
ALDH1A1 P00352 1/20 0.35
RECQL P46063 1/20 0.35
CHRNA7 P36544 1/20 0.35
HTR3A P46098 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14848749 0.84 CYP2A6 (0.56) CYP2A6MAPTTP53CA2THRB
SCHEMBL424317 0.82 CYP2A6 (0.48) CYP2A6MAPTTP53CA2THRB
SCHEMBL7541080 0.80 MAPT (0.45) CYP2A6MAPTTP53CA2THRB
SCHEMBL6608239 0.80 MAPT (0.46) CYP2A6MAPTTP53CA2THRB
SCHEMBL17140096 0.78 MAPT (0.44) CYP2A6MAPTTP53CA2THRB
SCHEMBL19099909 0.78 MAPT (0.44) CYP2A6MAPTTP53CA2THRB
SCHEMBL422138 0.78 CYP2A6 (0.50) CYP2A6MAPTTP53CA2THRB
SCHEMBL8147097 0.78 CA2 (0.47) CYP2A6MAPTTP53CA2THRB
SCHEMBL788066 0.78 CYP2A6 (0.60) CYP2A6MAPTTP53CA2LMNA
SCHEMBL5335374 0.78 CYP2A6 (0.60) CYP2A6MAPTCA2THRBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3339302-A1 PYRIDINE DERIVATIVE Teijin Pharma Limited (JP) 2018-06-27 EP claimed
US-20170190694-A1 PYRIDINE DERIVATIVE TEIJIN PHARMA LIMITED (JP) 2017-07-06 US claimed
EP-2944633-A1 PYRIDINE DERIVATIVE Teijin Pharma Limited (JP) 2015-11-18 EP claimed
US-12043749-B2 Method for producing ink composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-07-23 US disclosed
US-12043749-B2 Method for producing ink composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-07-23 US disclosed
US-11917839-B2 High signal-to-noise ratio photoelectric conversion element SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-02-27 US disclosed
US-11917839-B2 High signal-to-noise ratio photoelectric conversion element SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-02-27 US disclosed
US-20240023422-A1 COMPOSITION, FILM, ORGANIC PHOTOELECTRIC CONVERSION ELEMENT, AND PHOTODETECTION ELEMENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-01-18 US disclosed
US-20240023422-A1 COMPOSITION, FILM, ORGANIC PHOTOELECTRIC CONVERSION ELEMENT, AND PHOTODETECTION ELEMENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-01-18 US disclosed
US-11877459-B2 Light detecting element SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-01-16 US disclosed
US-11877459-B2 Light detecting element SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-01-16 US disclosed
US-7230020-B2 11β-hydroxysteroid dehydrogenase inhibitors STERIX LIMITED (GB) 2007-06-12 US disclosed
US-20070077506-A1 Electrophotographic photoreceptor and image forming apparatus provided with the same SHARP KABUSHIKI KAISHA (JP) 2007-04-05 US disclosed
US-20070077506-A1 Electrophotographic photoreceptor and image forming apparatus provided with the same SHARP KABUSHIKI KAISHA (JP) 2007-04-05 US disclosed
US-7175956-B2 Organic photoconductive material, electrophotographic photoreceptor comprising the same, and image-forming apparatus SHARP KABUSHIKI KAISHA (JP) 2007-02-13 US disclosed
US-7175956-B2 Organic photoconductive material, electrophotographic photoreceptor comprising the same, and image-forming apparatus SHARP KABUSHIKI KAISHA (JP) 2007-02-13 US disclosed
US-20070026334-A1 Electrophotographic photoreceptor and image forming apparatus including the same SHARP KABUSHIKI KAISHA (JP) 2007-02-01 US disclosed
US-20070026334-A1 Electrophotographic photoreceptor and image forming apparatus including the same SHARP KABUSHIKI KAISHA (JP) 2007-02-01 US disclosed
US-20030073832-A1 Novel aminophenyl ketone derivatives LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 2003-04-17 US disclosed
WO-2002083622-A2 NOVEL AMINOPHENYL KETONE DERIVATIVES LEO PHARMA A/S (DK) 2002-10-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030073832-A1 Novel aminophenyl ketone derivatives MAPKAPK2, MAP3K2, MAP3K1 CYP2A6 1648/4885MAPT 1188/4885TP53 3231/4885
US-20170190694-A1 PYRIDINE DERIVATIVE HPRT1, XDH, NUDT1 CYP2A6 1634/4885MAPT 451/4885TP53 3221/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.