Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233301 | 0.93 | METAP1 (0.45) | METAP1UBE2MDCUN1D1ADORA2ATSHR | |
| SCHEMBL4224157 | 0.91 | CASR (0.43) | METAP1UBE2MDCUN1D1CYP2D6ADORA2A | |
| SCHEMBL4234586 | 0.89 | CASR (0.43) | METAP1UBE2MDCUN1D1CYP2D6ADORA2A | |
| SCHEMBL4229354 | 0.89 | METAP1 (0.46) | METAP1UBE2MDCUN1D1CCR2ADORA2A | |
| SCHEMBL4223485 | 0.88 | MAPT (0.45) | MAPTUBE2MDCUN1D1CYP2D6OPRK1 | |
| SCHEMBL3235363 | 0.86 | CCR5 (0.38) | MAPTUBE2MDCUN1D1MEN1LMNA | |
| SCHEMBL3221276 | 0.85 | MEN1 (0.42) | MEN1KMT2A | |
| SCHEMBL4227705 | 0.84 | METAP1 (0.47) | METAP1ADORA2AMEN1LMNAMAPK1 | |
| SCHEMBL3228203 | 0.84 | SIGMAR1 (0.40) | MAPTCCR2LMNATSHRSMN1; SMN2 | |
| SCHEMBL4233242 | 0.83 | METAP1 (0.49) | METAP1ADORA2AMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |