SCHEMBL42335

SCHEMBL42335

Nc1ncnc2nc(O)[nH]c12

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.61
ADORA1 P30542 1/20 0.61
PI4KA P42356 8/20 0.57
PI4K2B Q8TCG2 8/20 0.57
PI4K2A Q9BTU6 8/20 0.57
PI4KB Q9UBF8 8/20 0.57
NUDT1 P36639 2/20 0.56
LMNA P02545 3/20 0.53
ALDH1A1 P00352 2/20 0.48
APEX1 P27695 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
TSHR P16473 2/20 0.47
DRD3 P35462 1/20 0.47
XDH P47989 1/20 0.47
LRRK2 Q5S007 1/20 0.47
ERBB2 P04626 1/20 0.45
HSP90AA1 P07900 1/20 0.45
HSP90AB1 P08238 1/20 0.45
PKM P14618 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29454410 1.00 ADORA2A (0.61) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL2639251 0.79 ADORA2A (0.37) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL42314 0.79 ADORA2A (0.66) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL29400753 0.79 ADORA2A (0.66) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL30109321 0.78 NUDT1 (0.68) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL1059581 0.78 NUDT1 (0.68) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL843169 0.76 ADORA2A (0.61) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL842891 0.76 ADORA2A (0.61) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL11918991 0.76 NUDT1 (0.36) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL842440 0.76 ADORA2A (0.61) ADORA2AADORA1PI4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4042 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630827-B2 Antisense oligonucleotides targeting SCN2A for the treatment of SCN1A encephalopathies ROGCON, INC. (US) 2026-05-19 US claimed
US-20250257360-A1 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER UNIV OKLAHOMA (US) 2025-08-14 US claimed
CN-113151261-B Antisense oligonucleotides as inhibitors of TGF-R signaling 神经视觉医药有限公司 2025-06-17 CN claimed
US-20250179503-A1 METHODS OF USING OLIGOMERIC COMPOUNDS TO TREAT SCN2A-RELATED DISORDERS PRAXIS PREC MEDICINES INC (US) 2025-06-05 US claimed
WO-2025110816-A1 COMBINATION THERAPY OF ANTICANCER TREATMENT WITH TOLL-LIKE RECEPTOR 7 OR 8 AGONIST HAVING ACTIVE SITE TEMPORARILY INACTIVATED FOR CANCER TREATMENT 프로지니어 주식회사 2025-05-30 WO claimed
US-20250146073-A1 METHODS FOR THE TREATMENT OF SCN2A-RELATED DISORDERS PRAXIS PREC MEDICINES INC (US) 2025-05-08 US claimed
EP-4506456-A1 NOVEL OXO-RNA COMPOSITIONS AND THE RELATED APPLICATIONS THEREOF Lin, Shi-Lung (US) 2025-02-12 EP claimed
EP-4504945-A2 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER The Board of Regents of the University of Oklahoma (US) 2025-02-12 EP claimed
US-12215343-B2 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-02-04 US claimed
US-20250019709-A1 NOVEL OXO-RNA COMPOSITIONS AND THE RELATED APPLICATIONS THEREOF LIN SHI LUNG (US) 2025-01-16 US claimed
US-6566514-B1 Antisense oligonucleotides for use in the treatment of tumors GENESENSE TECHNOLOGIES INC. (CA) 2003-05-20 US claimed
US-6548252-B1 Electrochemically analyzing samples from selected areas of the body of a living organism for elevated free levels of nucleotide excision products resulting from DNA or RNA damage ESA, INC. 2003-04-15 US claimed
US-6187551-B1 HYBRIDOMA CULTURE PRODUCT CYTOCHEM, INC. 2001-02-13 US claimed
EP-0898575-A2 A COMBINATORIAL PROTECTING GROUP STRATEGY FOR MULTIFUNCTIONAL MOLECULES KÖSTER, Hubert (US) 1999-03-03 EP claimed
EP-0706581-A4 DNA PROFILES AS AN INDICATOR OF CELLULAR REDOX POTENTIAL AND CANCER RISK PACIFIC NORTHWEST RESEARCH FOU (US) 1999-02-10 EP claimed
WO-1997041139-A2 A COMBINATORIAL PROTECTING GROUP STRATEGY FOR MULTIFUNCTIONAL MOLECULES KOESTER HUBERT (US) 1997-11-06 WO claimed
US-5665553-A Methods for determining and modulating cellular redox potential and genotoxic states PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1997-09-09 US claimed
US-5601981-A ASSAYING DNA FROM TEST SPECIMEN FOR CONCENTRATION OF RING-OPENED AND HYDROXYL DERIVATIVES, COMPARING, WHEREIN REDUCTIVE CELLULAR REDOX POTENTIAL EXISTS WHEN FORMATION OF RING-OPENED OVER HYDROXYL DERIVATIVES IS FAVORED PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1997-02-11 US claimed
EP-0706581-A1 DNA PROFILES AS AN INDICATOR OF CELLULAR REDOX POTENTIAL AND CANCER RISK PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1996-04-17 EP claimed
WO-1994025626-A1 DNA PROFILES AS AN INDICATOR OF CELLULAR REDOX POTENTIAL AND CANCER RISK PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1994-11-10 WO claimed