Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 4/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639251 | 0.79 | ADORA2A (0.37) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL3799507 | 0.79 | ADORA2A (0.37) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL3857164 | 0.78 | AKT2 (0.44) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL42335 | 0.76 | ADORA2A (0.61) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL5490464 | 0.76 | KDM4E (0.44) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL8823861 | 0.73 | — | — | |
| SCHEMBL9731613 | 0.73 | PI4KA (0.67) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL11280522 | 0.72 | ADORA2A (0.33) | ADORA2AADORA1NUDT1 | |
| SCHEMBL9503841 | 0.72 | PDPK1 (0.51) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL355788 | 0.72 | GSK3B (0.41) | ADORA2AADORA1NUDT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828308-B2 | Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2020-11-10 | — | — | US | disclosed |
| US-20190000854-A1 | TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE OR NON-ALCOHOLIC STEATOHEPATITIS WITH DELAYED-RELEASE 6-MERCAPTOPURINE | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2019-01-03 | — | — | US | disclosed |
| EP-3362053-A1 | TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE OR NON-ALCOHOLIC STEATOHEPATITIS WITH DELAYED-RELEASE 6-MERCAPTOPURINE | Teva Pharmaceutical Industries Ltd. (IL) | 2018-08-22 | — | — | EP | disclosed |
| US-20170105996-A1 | TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE OR NON-ALCOHOLIC STEATOHEPATITIS WITH DELAYED-RELEASE 6-MERCAPTOPURINE | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2017-04-20 | — | — | US | disclosed |
| WO-2017066619-A1 | TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE OR NON-ALCOHOLIC STEATOHEPATITIS WITH DELAYED-RELEASE 6-MERCAPTOPURINE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2017-04-20 | — | — | WO | disclosed |
| US-5635522-A | 4-NITRO-5-HETEROCYCLIC THIO-IMIDAZOLES; NONTOXIC TO BONE MARROW | THE UNIVERSITY OF SHEFFIELD (GB) | 1997-06-03 | — | — | US | disclosed |
| EP-0423221-B1 | IMMUNOSUPPRESSIVE AGENTS | UNIV SHEFFIELD (GB) | 1996-09-25 | — | — | EP | disclosed |
| US-5514697-A | 5-/BENZOTHIAZOLYLTHIO/-4-NITROIMIDAZOLES | THE UNIVERSITY OF SHEFFIELD (GB) | 1996-05-07 | — | — | US | disclosed |
| US-5300519-A | 4-Nitro-imidazole derivatives | THE UNIVERSITY OF SHEFFIELD (GB) | 1994-04-05 | — | — | US | disclosed |
| EP-0423221-A1 | IMMUNOSUPPRESSIVE AGENTS. | UNIV SHEFFIELD (GB) | 1991-04-24 | — | — | EP | disclosed |
| WO-1990000549-A1 | IMMUNOSUPPRESSIVE AGENTS | THE UNIVERSITY OF SHEFFIELD (GB) | 1990-01-25 | — | — | WO | disclosed |
| US-3969188-A | Method of producing guanosine by fermentation | AJINOMOTO CO., INC. (JA) | 1976-07-13 | — | — | US | disclosed |