Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 5/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30534246 | 0.81 | AKT2 (0.46) | NUDT1ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL2639251 | 0.79 | ADORA2A (0.37) | NUDT1ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL42335 | 0.76 | ADORA2A (0.61) | NUDT1ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL29454410 | 0.76 | ADORA2A (0.61) | NUDT1ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL6360434 | 0.76 | NUDT1 (0.36) | NUDT1ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL8823867 | 0.76 | ADORA2A (0.35) | NUDT1ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL320848 | 0.76 | NUDT1 (0.43) | NUDT1ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL9503841 | 0.76 | PDPK1 (0.51) | NUDT1ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL10217115 | 0.76 | FFAR2 (0.36) | NUDT1ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL355788 | 0.76 | GSK3B (0.41) | NUDT1ADORA2AADORA1GSK3BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358710-B1 | AKT AND P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2012-08-15 | — | — | EP | disclosed |