Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 19/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.79 |
| ▸ | TACR2 | P21452 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3639160 | 0.89 | P2RX3 (0.78) | P2RX3CYP2C9TACR2 | |
| SCHEMBL3677062 | 0.88 | P2RX3 (0.85) | P2RX3CYP2C9TACR2 | |
| SCHEMBL4234342 | 0.88 | P2RX3 (1.00) | P2RX3CYP2C9TACR2 | |
| SCHEMBL3634888 | 0.88 | P2RX3 (0.76) | P2RX3CYP2C9TACR2 | |
| SCHEMBL4223768 | 0.87 | P2RX3 (0.86) | P2RX3CYP2C9TACR2 | |
| SCHEMBL3671818 | 0.87 | P2RX3 (0.86) | P2RX3CYP2C9TACR2 | |
| SCHEMBL3666327 | 0.87 | P2RX3 (0.75) | P2RX3CYP2C9TACR2 | |
| SCHEMBL3636550 | 0.87 | P2RX3 (0.82) | P2RX3CYP2C9TACR2 | |
| SCHEMBL3641791 | 0.87 | P2RX3 (0.85) | P2RX3CYP2C9TACR2 | |
| SCHEMBL4224897 | 0.85 | P2RX3 (0.82) | P2RX3CYP2C9TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | claimed |
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20090099195-A1 | Therapeutic Compounds 570 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| WO-2008136756-A1 | PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099195-A1 | Therapeutic Compounds 570 | OPRL1, OPRK1, OPRM1 | P2RX3 53/4885CYP2C9 172/4885TACR2 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.