Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1373482 | 0.76 | GPR119 (0.54) | GPR119CHEK2USP30 | |
| SCHEMBL4234650 | 0.75 | GPR119 (0.53) | GPR119CHEK2USP30ALKDDB1 | |
| SCHEMBL5268593 | 0.73 | GPR119 (0.65) | GPR119CHEK2USP30 | |
| SCHEMBL1376612 | 0.72 | HRH3 (0.69) | GPR119CHEK2 | |
| SCHEMBL29749275 | 0.72 | GPR119 (0.62) | GPR119 | |
| SCHEMBL1087898 | 0.72 | GPR119 (0.62) | GPR119 | |
| SCHEMBL2366104 | 0.72 | GPR119 (0.64) | GPR119CHEK2USP30DDB1CRBN | |
| SCHEMBL1374893 | 0.71 | ALDH1A1 (0.52) | GPR119CHEK2 | |
| SCHEMBL2098964 | 0.71 | GPR119 (0.46) | GPR119CHEK2USP30 | |
| SCHEMBL27233564 | 0.71 | GPR119 (0.55) | GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |