Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28626652 | 0.80 | MAPT (0.43) | MAPTTDP1PDE4DALDH1A1KDM4E | |
| Methyl 2,3,4-Trimethoxybenzoate SCHEMBL1434191 | 0.79 | ALDH1A1 (0.57) | MAPTTDP1PDE4DALDH1A1KDM4E | |
| SCHEMBL28781948 | 0.77 | SMN1; SMN2 (0.39) | MAPTTDP1PDE4DALDH1A1KDM4E | |
| SCHEMBL24136599 | 0.76 | LMNA (0.55) | MAPTTDP1PDE4DALDH1A1KDM4E | |
| SCHEMBL30466421 | 0.76 | LMNA (0.55) | MAPTTDP1PDE4DALDH1A1KDM4E | |
| SCHEMBL23051546 | 0.76 | MAPT (0.51) | MAPTTDP1PDE4DALDH1A1KDM4E | |
| SCHEMBL1434290 | 0.76 | MAPT (0.71) | MAPTTDP1ALDH1A1KDM4EPOLB | |
| SCHEMBL315804 | 0.75 | LMNA (0.52) | MAPTALDH1A1KDM4EPOLBGAA | |
| SCHEMBL18280341 | 0.75 | MAPT (0.56) | MAPTTDP1PDE4DALDH1A1KDM4E | |
| SCHEMBL857226 | 0.75 | KDM4E (0.65) | MAPTTDP1PDE4DALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026248-A2 | HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) | 2009-02-26 | — | — | WO | disclosed |