Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGAV | P06756 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2841275 | 0.89 | ALDH1A1 (0.53) | ALDH1A1LMNAITGB3ITGAVPOLB | |
| SCHEMBL4235103 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNAITGB3ITGAVPOLB | |
| SCHEMBL2838961 | 0.85 | ALDH1A1 (0.53) | ALDH1A1LMNAITGB3ITGAVPOLB | |
| SCHEMBL2837257 | 0.83 | ITGB3 (0.51) | ALDH1A1LMNAITGB3ITGAVPOLB | |
| SCHEMBL2838894 | 0.83 | ALDH1A1 (0.48) | ALDH1A1LMNAITGB3ITGAVPOLB | |
| SCHEMBL2841463 | 0.81 | ITGB3 (0.56) | ALDH1A1LMNAITGB3ITGAV | |
| SCHEMBL2837716 | 0.80 | ITGB3 (0.53) | ALDH1A1LMNAITGB3ITGAVPOLB | |
| SCHEMBL2839386 | 0.80 | ITGB3 (0.52) | ALDH1A1LMNAITGB3ITGAVPOLB | |
| SCHEMBL2835176 | 0.80 | ALDH1A1 (0.48) | ALDH1A1LMNAITGB3ITGAVPOLB | |
| SCHEMBL2833027 | 0.79 | ALDH1A1 (0.48) | ALDH1A1LMNAITGB3ITGAVMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061448-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |