Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4236148 | 0.89 | ALDH1A1 (0.53) | ALDH1A1LMNAKCNK3KCNK9MEN1 | |
| SCHEMBL2835176 | 0.87 | ALDH1A1 (0.48) | ALDH1A1LMNAKCNK3KCNK9MEN1 | |
| SCHEMBL2837268 | 0.83 | MEN1 (0.46) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL4384849 | 0.81 | ITGB3 (0.47) | KCNK3KCNK9MEN1KMT2AITGB3 | |
| SCHEMBL2839431 | 0.81 | NAMPT (0.46) | ALDH1A1LMNAKCNK3ITGB3ITGAV | |
| SCHEMBL2841275 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAKCNK3KCNK9MEN1 | |
| SCHEMBL2838961 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAKCNK3KCNK9MEN1 | |
| SCHEMBL2838617 | 0.79 | ITGB3 (0.58) | KCNK3KCNK9ITGB3ITGAV | |
| SCHEMBL2836433 | 0.79 | MAPK1 (0.51) | LMNAKCNK3KCNK9MEN1KMT2A | |
| SCHEMBL2833513 | 0.79 | NPC1 (0.43) | ALDH1A1LMNAMEN1KMT2AITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061448-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |