Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.69 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.69 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.57 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.45 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL4240001 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL15794260 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL4237189 | 1.00 | TSHR (0.69) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL29291370 | 0.96 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL29291369 | 0.96 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL27548092 | 0.96 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL4348837 | 0.89 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7836361 | 0.89 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL2015893 | 0.89 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL10994264 | 0.89 | TSHR (0.64) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112336695-B | Propofol fumarate and tenofovir tablet, preparation method thereof and detection method of related substances | 华北制药华坤河北生物技术有限公司 | 2023-01-03 | — | — | CN | claimed |
| CN-112782311-B | HPLC (high performance liquid chromatography) determination method for L-isopropyl alanine in propane phenol fumarate tenofovir | 南京百泽医药科技有限公司 | 2022-12-27 | — | — | CN | claimed |
| CN-115337274-A | Propofol fumarate tenofovir tablets and preparation method thereof | 四川科伦药业股份有限公司 | 2022-11-15 | — | — | CN | claimed |
| CN-115260236-A | High-optical-purity intermediate for synthesizing propane fumarate tenofovir and preparation method thereof | 四川科伦药业股份有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-112294773-B | Pharmaceutical composition of propane fumarate and tenofovir | 石药集团中奇制药技术（石家庄）有限公司 | 2022-10-18 | — | — | CN | claimed |
| CN-114705765-A | High performance liquid detection method for L-isopropyl alaninate in propane fumarate tenofovir | 南京百泽医药科技有限公司 | 2022-07-05 | — | — | CN | claimed |
| CN-111189947-B | Analysis method for separating and detecting propane fumarate tenofovir disoproxil isomer | 济南新科医药科技有限公司 | 2022-06-17 | — | — | CN | claimed |
| CN-114605472-A | TAF oxidation degradation impurity, preparation method and application | 石家庄龙泽制药股份有限公司 | 2022-06-10 | — | — | CN | claimed |
| CN-114295767-B | Medicine impurity detection method based on propane fumarate tenofovir disoproxil tablets | 湖南明瑞制药有限公司 | 2022-06-03 | — | — | CN | claimed |
| CN-114527199-A | Method for separating and detecting enantiomers of fosaprepifuvir fumarate | 广东东阳光药业有限公司 | 2022-05-24 | — | — | CN | claimed |
| CN-114295767-A | Medicine impurity detection method based on propane fumarate tenofovir disoproxil tablets | 湖南明瑞制药有限公司 | 2022-04-08 | — | — | CN | claimed |
| CN-114053238-A | Preparation method of propane fumarate tenofovir disoproxil fumarate preparation | 南京百泽医药科技有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-113956293-A | Propofol fumarate tenofovir impurity TA-Q5 salt and preparation method and application thereof | 江苏科本药业有限公司 | 2022-01-21 | — | — | CN | claimed |
| CN-113125625-B | Method for detecting genotoxic impurities in propiofuravir fumarate | 天地恒一制药股份有限公司 | 2021-09-03 | — | — | CN | claimed |
| CN-113125625-A | Method for detecting genotoxic impurities in propiofuravir fumarate | 天地恒一制药股份有限公司 | 2021-07-16 | — | — | CN | claimed |
| CN-115792020-A | High performance liquid chromatography analysis and detection method for tenofovir and related substances | 福建南方济民医药研发中心有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-115677774-A | Phosphonate derivatives, their preparation and use | 上海医药工业研究院有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-101528666-A | Preparation of (R, R) -fenoterol and (R, R) -or (R, S) -fenoterol analogues and their use in the treatment of congestive heart failure | US GOVERNMENT (US) | 2009-09-09 | — | — | CN | disclosed |
| US-7021214-B2 | Method for issuing label with thermosensitive adhesive | RICOH COMPANY, LTD. (JP) | 2006-04-04 | — | — | US | disclosed |
| EP-1440888-A1 | Method for issuing a label with thermosensitive adhesive | Ricoh Company (JP) | 2004-07-28 | — | — | EP | disclosed |