Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238804 | 0.87 | ROCK2 (0.46) | ROCK2KDM1ABACE1MAPTPKM | |
| SCHEMBL4238780 | 0.87 | ROCK2 (0.46) | ROCK2KDM1ABACE1MAPTPKM | |
| SCHEMBL321174 | 0.84 | SLC6A4 (0.50) | ROCK2KDM1ASLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL321175 | 0.84 | SLC6A4 (0.50) | ROCK2KDM1ASLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL320857 | 0.84 | SLC6A4 (0.50) | ROCK2KDM1ASLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL1817686 | 0.81 | ROCK2 (0.49) | ROCK2KDM1ABACE1SLC6A4SLC6A3 | |
| SCHEMBL29352411 | 0.81 | ROCK2 (0.49) | ROCK2KDM1ABACE1SLC6A4SLC6A3 | |
| SCHEMBL1817691 | 0.81 | ROCK2 (0.49) | ROCK2KDM1ABACE1SLC6A4SLC6A3 | |
| SCHEMBL1817689 | 0.81 | ROCK2 (0.49) | ROCK2KDM1ABACE1SLC6A4SLC6A3 | |
| SCHEMBL15528627 | 0.78 | ROCK2 (0.32) | ROCK2BACE1SLC6A4SLC6A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038653-A2 | SUBSTRATES AND INHIBITORS OF ANTIPLASMIN CLEAVING ENZYME AND METHODS OF USE | McKee, Patrick A. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007146104-A2 | SUBSTRATES AND INHIBITORS OF ANTIPLASMIN CLEAVING ENZYME AND METHODS OF USE | MCKEE PATRICK A (US) | 2007-12-21 | — | — | WO | disclosed |