Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528628 | 0.81 | BACE1 (0.38) | ROCK2MAPTPKMBACE1 | |
| SCHEMBL15528626 | 0.81 | BACE1 (0.38) | ROCK2MAPTPKMBACE1 | |
| SCHEMBL4238784 | 0.78 | ROCK2 (0.45) | ROCK2SLC6A4SLC6A3MAPTPKM | |
| SCHEMBL4242723 | 0.72 | SLC6A3 (0.36) | ROCK2SLC6A3 | |
| SCHEMBL4238780 | 0.68 | ROCK2 (0.46) | ROCK2MAPTPKMBACE1 | |
| SCHEMBL4238804 | 0.68 | ROCK2 (0.46) | ROCK2MAPTPKMBACE1 | |
| SCHEMBL321175 | 0.68 | SLC6A4 (0.50) | ROCK2SLC6A4SLC6A3MAPTPKM | |
| SCHEMBL320857 | 0.68 | SLC6A4 (0.50) | ROCK2SLC6A4SLC6A3MAPTPKM | |
| SCHEMBL321174 | 0.68 | SLC6A4 (0.50) | ROCK2SLC6A4SLC6A3MAPTPKM | |
| SCHEMBL1817686 | 0.63 | ROCK2 (0.49) | ROCK2SLC6A4SLC6A3MAPTBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844246-A1 | SUBSTRATES AND INHIBITORS OF PROLYL OLIGOPEPTIDASE AND FIBROBLAST ACTIVATION PROTEIN AND METHODS OF USE | The Board of Regents of the University of Oklahoma (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166438-A1 | SUBSTRATES AND INHIBITORS OF PROLYL OLIGOPEPTIDASE AND FIBROBLAST ACTIVATION PROTEIN AND METHODS OF USE | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2013-11-07 | — | — | WO | disclosed |