Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 11/20 | 0.55 |
| ▸ | CDK9 | P50750 | 11/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.53 |
| ▸ | CCND1 | P24385 | 2/20 | 0.53 |
| ▸ | ABL2 | P42684 | 2/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | CDK7 | P50613 | 2/20 | 0.53 |
| ▸ | CCNH | P51946 | 2/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4240575 | 0.88 | AGPAT2 (0.56) | EGFRERBB3CCNT1CDK9MAP4K4 | |
| SCHEMBL4098867 | 0.87 | CDK9 (0.71) | CCNT1CDK9MAP4K4CDK1CDK4 | |
| SCHEMBL4238996 | 0.84 | ABL1 (0.55) | EGFRERBB3CCNT1CDK9MEN1 | |
| SCHEMBL4107964 | 0.83 | CDK5 (0.62) | EGFRERBB3CCNT1CDK9MEN1 | |
| SCHEMBL4109034 | 0.82 | CCNT1 (0.71) | EGFRERBB3CCNT1CDK9MEN1 | |
| SCHEMBL13777943 | 0.81 | TUBB4A (0.73) | EGFRERBB3CCNT1CDK9MEN1 | |
| SCHEMBL4114723 | 0.78 | CCNT1 (0.51) | CCNT1CDK9MEN1NPC1RAB9A | |
| SCHEMBL4108457 | 0.78 | CYP1A2 (0.58) | EGFRERBB3CCNT1CDK9MEN1 | |
| SCHEMBL4108197 | 0.77 | EGFR (0.53) | EGFRERBB3CCNT1CDK9NPC1 | |
| SCHEMBL28235042 | 0.77 | ALDH1A1 (0.46) | EGFRERBB3MEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181991-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC | 2009-07-16 | — | — | US | claimed |
| EP-1943233-A2 | COMPOUNDS AND COMPOSITIONS FOR PROTEIN KINASE INHBITORS | IRM, LLC (BM) | 2008-07-16 | — | — | EP | claimed |
| WO-2007056151-A2 | PROTEIN KINASE INHBITORS | IRM LLC (BM) | 2007-05-18 | — | — | WO | claimed |
| US-20090181991-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC | 2009-07-16 | — | — | US | disclosed |
| EP-1943233-A2 | COMPOUNDS AND COMPOSITIONS FOR PROTEIN KINASE INHBITORS | IRM, LLC (BM) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056151-A2 | PROTEIN KINASE INHBITORS | IRM LLC (BM) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181991-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | ERBB2, BMX, ERBB3 | EGFR 42/4885ERBB3 3/4885CCNT1 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.