Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | UBE2M | P61081 | 2/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.30 |
| ▸ | HTR2A | P28223 | 5/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.30 |
| ▸ | HTR2B | P41595 | 4/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.30 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4239992 | 0.87 | CCR5 (0.49) | CCR5UBE2MDCUN1D1OPRK1 | |
| SCHEMBL4242471 | 0.87 | CCR5 (0.51) | CCR5UBE2MDCUN1D1HTR2BSIGMAR1 | |
| SCHEMBL4244519 | 0.85 | CCR5 (0.51) | CCR5UBE2MDCUN1D1 | |
| SCHEMBL4242947 | 0.85 | CCR5 (0.46) | CCR5UBE2MDCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL4236434 | 0.85 | CCR5 (0.46) | CCR5UBE2MDCUN1D1 | |
| SCHEMBL4239108 | 0.84 | CCR5 (0.62) | CCR5UBE2MDCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL4240614 | 0.84 | CCR5 (0.46) | CCR5HTR1ADRD2DRD3OPRK1 | |
| SCHEMBL4240043 | 0.84 | CCR5 (0.46) | CCR5 | |
| SCHEMBL4236292 | 0.83 | CCR5 (0.47) | CCR5UBE2MDCUN1D1TSHR | |
| SCHEMBL4240442 | 0.82 | CCR5 (0.44) | CCR5UBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491735-B2 | Chemokine receptor binding compounds | GENZYME CORPORATION (US) | 2009-02-17 | — | — | US | disclosed |
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| US-20050277670-A1 | Chemokine receptor binding compounds | ANORMED INC. | 2005-12-15 | — | — | US | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277670-A1 | Chemokine receptor binding compounds | CCR5, CXCR3, CCL5 | CCR5 1/4885UBE2M 4562/4885DCUN1D1 3581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.