Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Penciclovir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 8/20 | 0.47 |
| ▸ | PNP | P00491 | 9/20 | 0.47 |
| ▸ | TK1 | P04183 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Penciclovir SCHEMBL454089 | 1.00 | HPRT1 (0.47) | HPRT1PNPTK1MEN1ALDH1A1 | |
| Penciclovir SCHEMBL3494 | 0.95 | TK1 (0.49) | HPRT1PNPTK1MEN1ALDH1A1 | |
| Penciclovir SCHEMBL15568622 | 0.89 | HPRT1 (0.42) | HPRT1PNPTK1MEN1ALDH1A1 | |
| SCHEMBL133681 | 0.88 | TK1 (0.43) | HPRT1PNPTK1MEN1ALDH1A1 | |
| SCHEMBL769982 | 0.88 | GAA (0.47) | HPRT1PNPTK1MEN1ALDH1A1 | |
| Water SCHEMBL15532449 | 0.87 | TK1 (0.42) | HPRT1PNPTK1MEN1ALDH1A1 | |
| SCHEMBL15046000 | 0.85 | GAA (0.42) | HPRT1PNPTK1MEN1ALDH1A1 | |
| SCHEMBL15257623 | 0.84 | KMT2A (0.42) | HPRT1PNPTK1MEN1ALDH1A1 | |
| SCHEMBL15045959 | 0.84 | GAA (0.43) | HPRT1PNPTK1MEN1ALDH1A1 | |
| Tiviciclovir SCHEMBL15531845 | 0.83 | BLM (0.45) | HPRT1PNPTK1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109627243-B | Penciclovir-copper complex, synthetic method and application thereof | 广西壮族自治区水产科学研究院 | 2021-06-29 | — | — | CN | disclosed |
| CN-108033987-B | Method for synthesizing houttuynin heterozygotic flavone Houttuynoid A | 暨南大学 | 2019-12-24 | — | — | CN | disclosed |
| CN-102423488-B | Medicine composition used for treating herpes zoster | SHIJIAZHUANG ZHONGSHUO PHARMACEUTICAL GROUP CO LTD | 2013-07-10 | — | — | CN | disclosed |
| CN-102423488-A | Pharmaceutical composition for treating herpes zoster | SHIJIAZHUANG ZHONGSHUO PHARMACEUTICAL GROUP CO LTD | 2012-04-25 | — | — | CN | disclosed |
| CN-101468014-B | Technique for preparing penciclovir emulsifiable paste | Shanghai Fosun Pharmaceutical (Group) Limited by Share Ltd. (CN) | 2012-02-15 | — | — | CN | disclosed |
| CN-100594889-C | Penciclovir freeze dried and method of manufacturing the same | Zhejiang jianfeng pharmaceutical co ltd | 2010-03-24 | — | — | CN | disclosed |
| CN-101468014-A | Technique for preparing penciclovir emulsifiable paste | SHANGHAI FOSUN PHARMACEUTICAL (CN) | 2009-07-01 | — | — | CN | disclosed |
| US-20090099154-A1 | Pharmaceutical Sustained Release Compositions and Processes Thereof | PANACEA BIOTEC LTD. (IN) | 2009-04-16 | — | — | US | disclosed |
| EP-1912628-A2 | PHARMACEUTICAL SUSTAINED RELEASE COMPOSITIONS AND PROCESSES THEREOF | Panacea Biotec Ltd. (IN) | 2008-04-23 | — | — | EP | disclosed |
| CN-101108169-A | Penciclovir freeze dried and method of manufacturing the same | ZHEJIANG JIAFENG PHARMACEUTICA (CN) | 2008-01-23 | — | — | CN | disclosed |
| WO-2007000779-A2 | PHARMACEUTICAL SUSTAINED RELEASE COMPOSITIONS AND PROCESSES THEREOF | PANACEA BIOTEC LTD. (IN) | 2007-01-04 | — | — | WO | disclosed |
| CN-1615874-A | Penciclovir solution and its preparing method and use | HE JIANG (CN) | 2005-05-18 | — | — | CN | disclosed |