Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 12/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | PRKACA | P17612 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 3/20 | 0.36 |
| ▸ | GSK3A | P49840 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.36 |
| ▸ | PRKX | P51817 | 3/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.36 |
| ▸ | STK3 | Q13188 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247704 | 0.90 | HTR3A (0.38) | ROCK1MALT1MEN1KMT2AF10 | |
| SCHEMBL4244710 | 0.89 | NTSR1 (0.39) | AKT1KDRMALT1MEN1KMT2A | |
| SCHEMBL4242997 | 0.89 | MALT1 (0.37) | CAPN1ROCK1MALT1ADRB2NCF1 | |
| Hydrochloric Acid SCHEMBL4236769 | 0.89 | HTR3A (0.38) | ROCK1MALT1MEN1KMT2AF10 | |
| Hydrochloric Acid SCHEMBL4236327 | 0.88 | MALT1 (0.36) | CAPN1ROCK1MALT1ADRB2NCF1 | |
| SCHEMBL4236291 | 0.87 | KDM4E (0.43) | ROCK2ROCK1DYRK1AMETKDR | |
| Hydrochloric Acid SCHEMBL4240482 | 0.86 | KDM4E (0.42) | ROCK2ROCK1DYRK1AMETKDR | |
| SCHEMBL4240969 | 0.83 | MALT1 (0.38) | ROCK1AKT1MALT1 | |
| SCHEMBL4245169 | 0.83 | MALT1 (0.37) | ROCK1MALT1ADRB2NCF1 | |
| SCHEMBL4241847 | 0.83 | PTGDR2 (0.41) | KDRMALT1KMT2AF10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531663-B2 | 3-guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-05-12 | — | — | US | claimed |
| US-20050026989-A1 | 3-Guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-02-03 | — | — | US | claimed |
| US-7531663-B2 | 3-guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-05-12 | — | — | US | disclosed |
| US-20050026989-A1 | 3-Guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026989-A1 | 3-Guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them | IDO1, IDO2, HTR3C | CAPN1 3205/4885DYRK3 460/4885ROCK2 1424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.