⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550879 | 0.82 | CA2 (0.41) | — | |
| SCHEMBL5144816 | 0.78 | TSHR (0.35) | — | |
| SCHEMBL304891 | 0.77 | CXCR2 (0.54) | — | |
| SCHEMBL11648181 | 0.77 | NPC1 (0.53) | — | |
| SCHEMBL4651553 | 0.77 | CA2 (0.40) | — | |
| SCHEMBL1920752 | 0.74 | CXCR2 (0.52) | — | |
| SCHEMBL4406660 | 0.74 | — | — | |
| SCHEMBL5852201 | 0.72 | — | — | |
| SCHEMBL1488039 | 0.72 | — | — | |
| SCHEMBL3849895 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101229106-A | Dye composition of acidic ph comprising 2,3-diamino-6,7-dihydro-1h,5h-pyrazolo[1,2-a]pyrazol-1-one, a para- phenylenediamine, a meta-aminophenol and an oxidizing agent | OREAL (FR) | 2008-07-30 | — | — | CN | claimed |
| CN-101204356-A | Dye composition of acidic ph comprising 2,3-diamino-6,7-dihydro-1h,5h-pyrazolo[1,2-a]pyrazol-1-one, a coupler, a particular surfactant and an oxidizing agent | OREAL (FR) | 2008-06-25 | — | — | CN | claimed |
| US-3989756-A | RANEY CATALYST, DEHALOGENATION INHIBITOR | NIPPON KAYAKU KABUSHIKI KAISHA (JA) | 1976-11-02 | — | — | US | claimed |
| JP-59174835-A | — | — | None | — | — | JP | disclosed |
| EP-3177616-B1 | NOVEL ROUTES OF SYNTHESIS FOR THE PREPARATION OF SUVOREXANT | SANDOZ AG (CH) | 2021-02-24 | — | — | EP | disclosed |
| CN-106573882-B | Synthetic route to suvorexant | 桑多斯股份公司 | 2020-09-01 | — | — | CN | disclosed |
| CN-104045552-B | Medicinal compound as neuroprotective agent | 江苏先声药业有限公司 | 2019-06-11 | — | — | CN | disclosed |
| CN-106536491-B | Benzoxazine keto-amide as mineralcorticoid receptor regulator | 阿斯利康(瑞典)有限公司 | 2018-12-18 | — | — | CN | disclosed |
| US-10030010-B2 | Route of synthesis for the preparation of suvorexant | SANDOZ AG (CH) | 2018-07-24 | — | — | US | disclosed |
| US-20170217947-A1 | Novel Route of Synthesis for the Preparation of Suvorexant | SANDOZ AG (CH) | 2017-08-03 | — | — | US | disclosed |
| EP-3177616-A1 | NOVEL ROUTES OF SYNTHESIS FOR THE PREPARATION OF SUVOREXANT | Sandoz AG (CH) | 2017-06-14 | — | — | EP | disclosed |
| US-5393305-A | Two-part aqueous composition for coloring hair, which forms a gel on mixing of the two parts | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0291588-B1 | SIZING AGENT | KABUSHIKI KAISHA CHIYODA KAGAKU KENKYUSHO (JP) | 1991-09-04 | — | — | EP | disclosed |
| EP-0291588-A1 | Sizing agent | KABUSHIKI KAISHA CHIYODA KAGAKU KENKYUSHO (JP) | 1988-11-23 | — | — | EP | disclosed |
| EP-0066248-B1 | PROCESS FOR THE PREPARATION OF HALOGENO-2-MERCAPTOBENZOXAZOLES | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-08-28 | — | — | EP | disclosed |
| JP-S59174835-A | DRY TYPE IMAGE FORMING METHOD | FUJI PHOTO FILM CO LTD | 1984-10-03 | — | — | JP | disclosed |
| US-4442294-A | Process for the preparation of halo-2-mercaptobenzoxazoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-04-10 | — | — | US | disclosed |
| EP-0066248-A1 | Process for the preparation of halogeno-2-mercaptobenzoxazoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-12-08 | — | — | EP | disclosed |
| US-3989756-A | RANEY CATALYST, DEHALOGENATION INHIBITOR | NIPPON KAYAKU KABUSHIKI KAISHA (JA) | 1976-11-02 | — | — | US | disclosed |
| US-3947247-A | STABILIZER COMPOSITION FOR DYESTUFFS | CENTRAL MICHIGAN UNIVERSITY BOARD OF TRUSTEES (US) | 1976-03-30 | — | — | US | disclosed |