Sugi Predict

Sugi Predict / Compounds / SCHEMBL4242916

SCHEMBL4242916

SCHEMBL4242916

NC(c1ccccc1-c1ccccc1C(=O)NCc1ccccc1)S(=O)(=O)c1cccc(F)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CHRNB2 P17787 1/20 0.46
▸ CHRNB4 P30926 1/20 0.46
▸ CHRNA3 P32297 1/20 0.46
▸ CHRNA4 P43681 1/20 0.46
▸ CA4 P22748 2/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ KMT2A Q03164 4/20 0.42
▸ CYP1A2 P05177 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ LMNA P02545 3/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ MEN1 O00255 2/20 0.42
▸ GAA P10253 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ NSD2 O96028 2/20 0.41
▸ KCNA5 P22460 1/20 0.41
▸ CA1 P00915 2/20 0.41
▸ CA2 P00918 2/20 0.41
▸ HTT P42858 1/20 0.41
▸ GBA1 P04062 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4245385 0.90 RAB9A (0.46) RAB9ALMNAALDH1A1KCNA5CA1
SCHEMBL4248727 0.86 ALDH1A1 (0.50) CHRNB2CHRNB4CHRNA3CHRNA4CA4
SCHEMBL4240140 0.84 GBA1 (0.43) KMT2ACYP1A2LMNAALDH1A1MEN1
SCHEMBL4238995 0.81 HTT (0.47) CA4RAB9AKMT2ALMNAALDH1A1
SCHEMBL2207422 0.78 KCNA5 (0.58) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A
SCHEMBL4247417 0.76 ALDH1A1 (0.53) RAB9AKMT2ALMNAALDH1A1MEN1
SCHEMBL4240832 0.71 ALDH1A1 (0.41) KMT2ALMNAALDH1A1MEN1GAA
SCHEMBL4248643 0.71 CA1 (0.46) RAB9AKMT2ALMNAALDH1A1MEN1
SCHEMBL2210421 0.69 KCNA5 (0.60) RAB9AKCNA5HTTMAPT
SCHEMBL7828799 0.68 KMT2A (0.77) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7514582-B2 2′-substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-04-07 — — US disclosed
US-20040102513-A1 2'-Substituted 1,1'-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them AVENTIS PHARMA DEUTSCHLAND GMBH 2004-05-27 — — US disclosed
US-20030171351-A1 2'-substituted 1,1'-biphenyl-2-carboxamides, process for their preparation, their use as medicaments, and pharmaceutical preparations comprising them AVENTIS PHARMA DEUTSCHLAND GMBH 2003-09-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030171351-A1 2'-substituted 1,1'-biphenyl-2-carboxamides, process for their preparation, their use as medicaments, and pharmaceutical preparations comprising them MLLT3, RYR2, KCNH1 CHRNB2 1479/4885CHRNB4 1599/4885CHRNA3 867/4885
US-20040102513-A1 2'-Substituted 1,1'-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them MLLT3, RYR2, CACNA1E CHRNB2 1535/4885CHRNB4 1671/4885CHRNA3 884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.