SCHEMBL4243036

SCHEMBL4243036

COCc1nc(-c2ccc(OCCC(F)(F)F)cc2)c(-c2ccc(Cl)cc2)nc1C(O)=S

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 3/20 0.48
PTGDR2 Q9Y5Y4 2/20 0.35
MAPT P10636 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
SLC2A1 P11166 1/20 0.33
MGAT2 Q10469 2/20 0.33
AGER Q15109 1/20 0.33
PPARA Q07869 2/20 0.33
FFAR1 O14842 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33
PTPN11 Q06124 1/20 0.32
FDPS P14324 2/20 0.32
MRGPRX4 Q96LA9 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
PPARG P37231 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4599786 0.89 CNR1 (0.47) CNR1MGAT2FFAR1FFAR4
SCHEMBL4243035 0.89 CNR1 (0.48) CNR1PTGDR2PPARAFFAR1FFAR4
SCHEMBL4247679 0.85 CNR1 (0.57) CNR1PTGDR2SLC2A1
SCHEMBL4599782 0.84 CNR1 (0.42) CNR1PTGDR2SMN1; SMN2MGAT2FFAR1
SCHEMBL4600547 0.73 CNR1 (0.69) CNR1SLC2A1
SCHEMBL4681021 0.73 CNR1 (0.57) CNR1PTGDR2SMN1; SMN2SLC2A1MRGPRX4
SCHEMBL4248289 0.71 CNR1 (0.61) CNR1FFAR1FFAR4
SCHEMBL4247678 0.71 CNR1 (0.57) CNR1PTGDR2MAPTSMN1; SMN2SLC2A1
SCHEMBL4600541 0.71 CNR1 (0.65) CNR1PTGDR2SMN1; SMN2
SCHEMBL4680862 0.70 CNR1 (0.59) CNR1PTGDR2MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090156616-A1 THERAPEUTIC AGENTS ASTRAZENECA AB (SE) 2009-06-18 US claimed
US-20090156616-A1 THERAPEUTIC AGENTS ASTRAZENECA AB (SE) 2009-06-18 US disclosed
EP-1910304-A2 THERAPEUTIC AGENTS AstraZeneca AB (SE) 2008-04-16 EP disclosed
WO-2007010222-A2 THERAPEUTIC AGENTS ASTRAZENECA AB (SE) 2007-01-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156616-A1 THERAPEUTIC AGENTS NLN, BDNF, GAP43 CNR1 173/4885PTGDR2 379/4885MAPT 291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.