SCHEMBL4243280

SCHEMBL4243280

Nc1ccc(C=C(c2ccccc2)c2cccc3ccccc23)c(-c2ccccc2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.39
MEN1 O00255 5/20 0.39
MAPT P10636 4/20 0.39
HTT P42858 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CDK4 P11802 1/20 0.38
CCND1 P24385 1/20 0.38
ALDH1A1 P00352 4/20 0.36
HPGD P15428 4/20 0.36
HSD17B10 Q99714 2/20 0.36
KDM4E B2RXH2 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
APAF1 O14727 1/20 0.36
TP53 P04637 1/20 0.36
ALOX15 P16050 1/20 0.36
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36
NR4A1 P22736 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27470383 0.86 CDK4 (0.35) KMT2AMEN1MAPTHTTCDK4
SCHEMBL27792351 0.85 BCAT2 (0.39) KMT2AMEN1MAPTHTTTDP1
SCHEMBL27913794 0.84 KMT2A (0.41) KMT2AMEN1MAPTHTTTDP1
SCHEMBL22125988 0.84 MMP9 (0.35) KMT2AMEN1MAPTHTTTDP1
SCHEMBL4246291 0.82 KMT2A (0.40) KMT2AMEN1MAPTHTTTDP1
SCHEMBL1539828 0.80 CYP3A4 (0.41) KMT2AMEN1MAPTHTTTDP1
SCHEMBL2506549 0.78 NR4A1 (0.43) KMT2AMEN1MAPTHTTNPSR1
SCHEMBL2506548 0.78 NR4A1 (0.43) KMT2AMEN1MAPTHTTNPSR1
SCHEMBL28005325 0.77 ADORA2A (0.36) KMT2AMEN1MAPTTDP1L3MBTL1
SCHEMBL1414517 0.74 GUSB (0.35) KMT2AMEN1MAPTTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103242167-A Amine compound, electrophotographic photoconductor, image forming method, image forming apparatus, and process cartridge RICOH CO LTD 2013-08-14 CN disclosed
US-8380109-B2 Image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2013-02-19 US disclosed
CN-101320227-B Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH CO., LTD. (JP) 2011-12-07 CN disclosed
US-20090180804-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2009-07-16 US disclosed
CN-101320227-A Electrophotographic photoreceptor, image forming apparatus, and process cartridge RICOH KK (JP) 2008-12-10 CN disclosed
CN-1169025-C Electronic photographic photoreceptor 株式会社理光 2004-09-29 CN disclosed
CN-1196506-A Electronic photographic photoreceptor RICOH KK (JP) 1998-10-21 CN disclosed