SCHEMBL4246291

SCHEMBL4246291

Nc1ccc(C=C(c2ccccc2)c2ccc(C(=Cc3ccc(N)cc3-c3ccccc3)c3ccccc3)cc2)c(-c2ccccc2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.40
TLR9 Q9NR96 2/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.40
ATM Q13315 1/20 0.40
ALDH1A1 P00352 3/20 0.36
MAPT P10636 3/20 0.36
HPGD P15428 3/20 0.36
MEN1 O00255 3/20 0.36
KDM4E B2RXH2 2/20 0.36
GLA P06280 2/20 0.36
GAA P10253 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
NPC1 O15118 2/20 0.36
HTT P42858 1/20 0.36
RAB9A P51151 1/20 0.36
GFER P55789 1/20 0.36
RCE1 Q9Y256 1/20 0.36
PKM P14618 1/20 0.36
MAOA P21397 1/20 0.36
ESR1 P03372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27913794 0.98 KMT2A (0.41) KMT2ATLR9PTGDR2ATMALDH1A1
SCHEMBL1539828 0.97 CYP3A4 (0.41) KMT2ATLR9PTGDR2ATMALDH1A1
SCHEMBL28037210 0.90 EPRS1 (0.39) KMT2ATLR9PTGDR2ATMALDH1A1
SCHEMBL27792351 0.88 BCAT2 (0.39) KMT2ATLR9PTGDR2ATMALDH1A1
SCHEMBL22125988 0.83 MMP9 (0.35) KMT2ATLR9PTGDR2ATMALDH1A1
SCHEMBL6013880 0.83 NPC1 (0.37) KMT2AALDH1A1MAPTHPGDMEN1
SCHEMBL4243280 0.82 KMT2A (0.39) KMT2ATLR9PTGDR2ATMALDH1A1
SCHEMBL28005325 0.81 ADORA2A (0.36) KMT2APTGDR2ALDH1A1MAPTHPGD
SCHEMBL28304106 0.79 CYP19A1 (0.41) ALDH1A1MAPTHPGDSMN1; SMN2ESR1
SCHEMBL27470383 0.79 CDK4 (0.35) KMT2ATLR9PTGDR2ATMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8380109-B2 Image forming apparatus and process cartridge RICOH COMPANY, LTD. (JP) 2013-02-19 US disclosed
US-20090180804-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2009-07-16 US disclosed
EP-0926557-B1 Electrophotographic photoreceptor, process for producing the same, and use of said photoreceptor for forming an image SHARP KK (JP) 2006-11-22 EP disclosed
US-6054237-A ELECTROPHOTOGRAPHIC PHOTORECEPTOR WHERE THE CHARGE GENERATING LAYER COMPRISES A TAU-TYPE NONMETALLIC PHTHALOCYANINE HAVING ONE OR MORE PEAKS AT BRAGG'S ANGLE AND COPOLYMERS OF VINYL ACETATE-VINYL CHLORIDE; APPARATUS FOR INVERSION DEVELOPMENT SHARP KABUSHIKI KAISHA (JP) 2000-04-25 US disclosed
EP-0926557-A1 Electrophotographic photoreceptor, process for producing the same, and image forming apparatus using same Sharp Kabushiki Kaisha (JP) 1999-06-30 EP disclosed