Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | BCL6 | P41182 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062797 | 0.86 | ALDH1A1 (0.40) | CTSLCTSSCTSKBCL6 | |
| SCHEMBL5062800 | 0.86 | ALDH1A1 (0.40) | CTSLCTSSCTSKBCL6 | |
| Nitrous Acid SCHEMBL4243378 | 0.84 | ALDH1A1 (0.36) | CTSLCTSSCTSKBCL6 | |
| SCHEMBL5597276 | 0.67 | ALDH1A1 (0.34) | — | |
| SCHEMBL4249002 | 0.60 | RPS6KA5 (0.72) | — | |
| SCHEMBL24896370 | 0.56 | KDM4C (0.40) | — | |
| SCHEMBL29942346 | 0.55 | CDC7 (0.34) | CTSLCTSSCTSKBCL6 | |
| SCHEMBL26660761 | 0.55 | CTSL (0.34) | CTSLCTSSCTSKBCL6 | |
| SCHEMBL23756415 | 0.55 | CDC7 (0.34) | CTSLCTSSCTSKBCL6 | |
| SCHEMBL2476573 | 0.54 | NOTUM (0.38) | BCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |