Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 4/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062800 | 1.00 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2POLBHPGDL3MBTL1 | |
| Nitrous Acid SCHEMBL4243378 | 0.94 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2POLBHPGDL3MBTL1 | |
| SCHEMBL4243375 | 0.86 | CTSL (0.31) | CTSLCTSSCTSKBCL6 | |
| SCHEMBL5597276 | 0.79 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2POLBHPGDL3MBTL1 | |
| SCHEMBL5597279 | 0.79 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2POLBHPGDL3MBTL1 | |
| SCHEMBL4249002 | 0.65 | RPS6KA5 (0.72) | ALDH1A1RPS6KA5 | |
| SCHEMBL691439 | 0.64 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2POLBHPGDL3MBTL1 | |
| SCHEMBL691440 | 0.64 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2POLBHPGDL3MBTL1 | |
| SCHEMBL5065108 | 0.64 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2POLBHPGDL3MBTL1 | |
| SCHEMBL5065109 | 0.64 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2POLBHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | ALDH1A1 4166/4885SMN1; SMN2 3299/4885POLB 1321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.