Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.40 |
| ▸ | CTSS | P25774 | 7/20 | 0.36 |
| ▸ | CTSB | P07858 | 6/20 | 0.36 |
| ▸ | CTSL | P07711 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4243855 | 0.81 | CTSK (0.33) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4243604 | 0.80 | CTSL (0.37) | CTSKCTSSCTSBCTSL | |
| SCHEMBL3881247 | 0.79 | CTSK (0.34) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4063005 | 0.78 | CTSC (0.34) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4242428 | 0.78 | CTSK (0.32) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4245817 | 0.72 | CTSS (0.40) | CTSKCTSSCTSBCTSL | |
| SCHEMBL7074903 | 0.72 | CTSS (0.39) | CTSKCTSSCTSBCTSL | |
| SCHEMBL7571642 | 0.71 | CTSL (0.43) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4239823 | 0.71 | CTSS (0.51) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4250968 | 0.71 | CTSS (0.43) | CTSKCTSSCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | disclosed |
| EP-2032535-B1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI SA (FR) | 2012-08-01 | — | — | EP | disclosed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |