Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.57 |
| ▸ | EGFR | P00533 | 7/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.52 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | DHPS | P49366 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | GOT1 | P17174 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27463226 | 0.82 | MEN1 (0.59) | MAPK14EGFRAHRDHPSMAPK1 | |
| SCHEMBL2986147 | 0.81 | MAPK14 (0.57) | MAPK14EGFRAURKAMAPK1PDGFRB | |
| SCHEMBL2976781 | 0.78 | DHPS (0.48) | EGFRDHPSMAPK1PDGFRBKDR | |
| SCHEMBL858905 | 0.78 | MAPK14 (0.60) | MAPK14AURKAMAPK1GAKRET | |
| SCHEMBL21257478 | 0.78 | RAPGEF4 (0.46) | MAPK14EGFRDHPSMAPK1PDGFRB | |
| SCHEMBL14137199 | 0.75 | EGFR (0.57) | EGFRGAKRAPGEF4 | |
| SCHEMBL31744708 | 0.75 | STING1 (0.52) | MAPK14EGFRAURKAAURKBINCENP | |
| SCHEMBL15455646 | 0.74 | MAPK1 (0.47) | MAPK14EGFRAHRDHPSMAPK1 | |
| SCHEMBL9132873 | 0.74 | MAPK1 (0.51) | MAPK14EGFRAHRDHPSMAPK1 | |
| SCHEMBL29831041 | 0.74 | MAPK14 (1.00) | MAPK14EGFRAURKAAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029543-B1 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH LLC (US) | 2015-11-18 | — | — | EP | disclosed |
| EP-2029543-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007146376-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |