Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL28168775 | 0.87 | MAPK14 (0.52) | MAPK14RETFBP1PRKCBMEN1 | |
| SCHEMBL31744572 | 0.83 | PRKCB (0.60) | MAPK14PRKCBMEN1KMT2AMAPT | |
| SCHEMBL7993463 | 0.80 | TNNI3K (0.60) | FBP1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL2984223 | 0.79 | RET (0.46) | MAPK14RETMEN1KMT2AMAPK1 | |
| SCHEMBL27463226 | 0.78 | MEN1 (0.59) | MAPK14RETMEN1KMT2AMAPT | |
| SCHEMBL1921497 | 0.78 | MEN1 (0.62) | MAPK14MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL2986147 | 0.78 | MAPK14 (0.57) | MAPK14RETMAPK1TSHRERBB2 | |
| SCHEMBL4245668 | 0.78 | MAPK14 (0.57) | MAPK14RETMAPK1RAPGEF4GAK | |
| SCHEMBL21257478 | 0.77 | RAPGEF4 (0.46) | MAPK14RETMAPK1RAPGEF4GRM4 | |
| SCHEMBL31744804 | 0.77 | PRKCB (0.51) | MAPK14FBP1PRKCBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |