SCHEMBL4246767

SCHEMBL4246767

CC(C)OC(=O)C(I)C(I)C(=O)OC(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.48
HCAR2 Q8TDS4 1/20 0.37
CA12 O43570 7/20 0.35
CA1 P00915 7/20 0.35
CA2 P00918 7/20 0.35
CA9 Q16790 7/20 0.35
CA7 P43166 4/20 0.33
CA14 Q9ULX7 4/20 0.33
LMNA P02545 3/20 0.33
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
ADRA1A P35348 1/20 0.32
PDE4D Q08499 1/20 0.32
KDM4E B2RXH2 2/20 0.31
USP2 O75604 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HSD17B10 Q99714 1/20 0.31
PDCD1 Q15116 1/20 0.30
CD274 Q9NZQ7 1/20 0.30
PPARG P37231 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21811751 0.82
SCHEMBL28965299 0.75 TSHR (0.53) TSHRHCAR2CA12CA1CA2
SCHEMBL4585366 0.75 TSHR (0.53) TSHRHCAR2CA12CA1CA2
SCHEMBL295903 0.75
SCHEMBL8019158 0.74 TSHR (0.46) TSHRHCAR2CA12CA1CA2
SCHEMBL8016407 0.74 TSHR (0.40) TSHRHCAR2LMNA
SCHEMBL21811517 0.74 TSHR (0.40) TSHRHCAR2LMNAALDH1A1
SCHEMBL4254646 0.74 MAPT (0.41) TSHRLMNAALDH1A1
SCHEMBL11518736 0.73 TSHR (0.50) TSHRHCAR2CA12CA1CA2
SCHEMBL6180156 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL TSHR 1710/4885HCAR2 354/4885CA12 2505/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL TSHR 1710/4885HCAR2 354/4885CA12 2505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.