Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19057196 | 0.85 | ALDH1A1 (0.56) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 | |
| SCHEMBL27509184 | 0.85 | ALDH1A1 (0.56) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 | |
| SCHEMBL676433 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 | |
| SCHEMBL156493 | 0.81 | ALDH1A1 (0.63) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 | |
| SCHEMBL15797836 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 | |
| SCHEMBL10383976 | 0.81 | TDP1 (0.55) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 | |
| SCHEMBL14530533 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 | |
| SCHEMBL13189381 | 0.81 | ALDH1A1 (0.63) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 | |
| SCHEMBL8259800 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 | |
| SCHEMBL5367985 | 0.79 | TDP1 (0.59) | ALDH1A1TDP1SLC6A2SLC6A3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678765-B2 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them | PHARMA MAR, S.A. (ES) | 2010-03-16 | — | — | US | disclosed |
| EP-2022481-A1 | Conditioning composition for keratinic fibres | KPSS-Kao Professional Salon Services GmbH (DE) | 2009-02-11 | — | — | EP | disclosed |
| US-7348310-B2 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them | PHARMA MAR, S.A. (ES) | 2008-03-25 | — | — | US | disclosed |
| US-20080009435-A1 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them | PHARMA MAR, S.A., A SPAIN CORPORATION | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009435-A1 | Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them | MCL1, APLNR, PAICS | ALDH1A1 1787/4885TDP1 1683/4885SLC6A2 4420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.