SCHEMBL676433

SCHEMBL676433

C=C([SiH3])OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.52
TDP1 Q9NUW8 2/20 0.50
SLC6A2 P23975 2/20 0.50
SLC6A3 Q01959 2/20 0.50
MAPK1 P28482 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
KMT2A Q03164 1/20 0.50
TSHR P16473 2/20 0.48
LMNA P02545 4/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HCAR2 Q8TDS4 1/20 0.46
IDO1 P14902 1/20 0.44
AGXT P21549 1/20 0.43
CYP1A2 P05177 1/20 0.42
PTGS1 P23219 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4246837 0.81 ALDH1A1 (0.56) ALDH1A1TDP1SLC6A2SLC6A3MAPK1
SCHEMBL19057196 0.81 ALDH1A1 (0.56) ALDH1A1TDP1SLC6A2SLC6A3MAPK1
SCHEMBL1162483 0.77 ALDH1A1 (0.63) ALDH1A1TDP1SLC6A2SLC6A3MAPK1
SCHEMBL10383976 0.77 TDP1 (0.55) ALDH1A1TDP1SLC6A2SLC6A3MAPK1
SCHEMBL13189381 0.77 ALDH1A1 (0.63) ALDH1A1TDP1SLC6A2SLC6A3MAPK1
SCHEMBL8259800 0.77 ALDH1A1 (0.52) ALDH1A1TDP1SLC6A2SLC6A3MAPK1
SCHEMBL15797836 0.77 ALDH1A1 (0.52) ALDH1A1TDP1SLC6A2SLC6A3MAPK1
SCHEMBL156493 0.77 ALDH1A1 (0.63) ALDH1A1TDP1SLC6A2SLC6A3MAPK1
SCHEMBL14530533 0.77 ALDH1A1 (0.52) ALDH1A1TDP1SLC6A2SLC6A3MAPK1
SCHEMBL3421040 0.76 ALDH1A1 (0.50) ALDH1A1TDP1SLC6A2SLC6A3MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9512272-B2 Curable composition containing silicone, and cured product thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2016-12-06 US disclosed
US-20150322211-A1 Curable Composition Containing Silicone, and Cured Product Thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2015-11-12 US disclosed
EP-1746132-B1 SILICON-CONTAINING CURABLE COMPOSITION AND CURED OBJECT OBTAINED BY THERMALLY CURING THE SAME ADEKA CORP (JP) 2013-07-10 EP disclosed
EP-1801871-B1 SEMICONDUCTOR DEVICE KANSAI ELECTRIC POWER CO (JP) 2012-07-11 EP disclosed
US-7939614-B2 Silicon-containing curing composition and heat cured product thereof ADEKA CORPORATION (JP) 2011-05-10 US disclosed
US-7772594-B2 covered with a synthetic high molecular compound which is a silicon-containing curable polymer composition having excellent heat resistance and flexibility; high voltage; fluorine-free; platinum curing catalyst THE KANSAI ELECTRIC POWER CO., INC. (JP) 2010-08-10 US disclosed
US-20080210948-A1 High-Heat-Resistive Semiconductor Device THE KANSAI ELECTRIC POWER CO., INC. (JP) 2008-09-04 US disclosed
US-20070197755-A1 Silicon-containing curing composition and heat cured product thereof ADEKA CORPORATION (JP) 2007-08-23 US disclosed
EP-1801871-A1 SEMICONDUCTOR DEVICE THE KANSAI ELECTRIC POWER CO., INC. (JP) 2007-06-27 EP disclosed
EP-1746132-A1 SILICON-CONTAINING CURABLE COMPOSITION AND CURED OBJECT OBTAINED BY THERMALLY CURING THE SAME Adeka Corporation (JP) 2007-01-24 EP disclosed