Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27269511 | 0.78 | PDPK1 (0.40) | PDPK1EGLN1LMNAPARP1ALDH1A1 | |
| SCHEMBL27929366 | 0.74 | — | — | |
| SCHEMBL1081796 | 0.73 | EGLN1 (0.46) | PDPK1EGLN1LMNAPARP1ALDH1A1 | |
| SCHEMBL24241002 | 0.71 | MEN1 (0.37) | LMNAPARP1ALDH1A1PKMMEN1 | |
| SCHEMBL21137030 | 0.70 | PARP1 (0.46) | PDPK1PARP1ALDH1A1MEN1KMT2A | |
| SCHEMBL19329710 | 0.68 | EGLN1 (0.35) | EGLN1LMNAPARP1ALDH1A1PKM | |
| SCHEMBL1080012 | 0.67 | EGLN1 (0.62) | EGLN1 | |
| SCHEMBL14722366 | 0.66 | ALDH1A1 (0.38) | EGLN1LMNAPARP1ALDH1A1PKM | |
| SCHEMBL2362289 | 0.65 | LMNA (0.34) | LMNAPARP1ALDH1A1PKMMEN1 | |
| SCHEMBL3855175 | 0.64 | MEN1 (0.42) | PDPK1LMNAPARP1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134850-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-05 | — | — | WO | claimed |