Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 7/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 7/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 7/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 7/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443096 | 0.91 | ALDH1A1 (0.53) | ALDH1A1HTTNPC1RAB9ATSHR | |
| SCHEMBL4252421 | 0.80 | PKM (0.56) | ALDH1A1HTTNPC1RAB9ATSHR | |
| SCHEMBL4252435 | 0.72 | KDM4E (0.49) | ALDH1A1NPC1TSHRLMNAKDM4E | |
| SCHEMBL445247 | 0.70 | PKM (0.58) | ALDH1A1NPC1RAB9ATSHRLMNA | |
| SCHEMBL4253856 | 0.70 | MEN1 (0.50) | ALDH1A1NPC1RAB9ALMNAMAPK1 | |
| SCHEMBL4255199 | 0.69 | RAB9A (0.51) | ALDH1A1HTTNPC1RAB9ATSHR | |
| SCHEMBL4251410 | 0.69 | NAMPT (0.58) | — | |
| SCHEMBL4254267 | 0.68 | HRH3 (0.42) | ALDH1A1NPC1RAB9ATSHRLMNA | |
| SCHEMBL4251760 | 0.68 | HPGD (0.48) | ALDH1A1HTTNPC1RAB9ATSHR | |
| SCHEMBL4251082 | 0.67 | MAPT (0.56) | ALDH1A1HTTTSHRLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | ALDH1A1 601/4885HTT 197/4885NPC1 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.