SCHEMBL4247657

SCHEMBL4247657

COC(=O)C=C(Oc1ccccc1[N+](=O)[O-])C(=O)OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.54
POLB P06746 1/20 0.54
MAPT P10636 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
ALDH1A1 P00352 6/20 0.50
TDP1 Q9NUW8 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.49
HTT P42858 2/20 0.44
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
KDM4E B2RXH2 1/20 0.43
NPC1 O15118 1/20 0.42
RECQL P46063 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CES2 O00748 1/20 0.42
ACHE P22303 1/20 0.42
CES1 P23141 1/20 0.42
AR P10275 1/20 0.41
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4249662 1.00 RAB9A (0.54) RAB9APOLBMAPTNPSR1ALDH1A1
SCHEMBL4247652 1.00 RAB9A (0.54) RAB9APOLBMAPTNPSR1ALDH1A1
SCHEMBL19744209 0.83 ATM (0.43) POLBMAPTALDH1A1HTTNPC1
SCHEMBL19744095 0.83 ATM (0.43) POLBMAPTALDH1A1HTTNPC1
SCHEMBL4247745 0.81 RAB9A (0.58) RAB9APOLBMAPTALDH1A1TDP1
SCHEMBL4254520 0.81 ALDH1A1 (0.47) RAB9APOLBMAPTNPSR1ALDH1A1
SCHEMBL4252109 0.81 RAB9A (0.58) RAB9APOLBMAPTALDH1A1TDP1
SCHEMBL4247741 0.81 RAB9A (0.58) RAB9APOLBMAPTALDH1A1TDP1
SCHEMBL4251479 0.81 ALDH1A1 (0.47) RAB9APOLBMAPTNPSR1ALDH1A1
SCHEMBL4251473 0.81 ALDH1A1 (0.47) RAB9APOLBMAPTNPSR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL RAB9A 3116/4885POLB 2938/4885MAPT 4765/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL RAB9A 3116/4885POLB 2938/4885MAPT 4765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.