Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443004 | 0.90 | HDAC6 (0.55) | HDAC6HDAC1NPC1PLK1BCAT1 | |
| SCHEMBL4248905 | 0.87 | NPC1 (0.51) | HDAC6HDAC1NPC1BCAT1HTT | |
| SCHEMBL4252430 | 0.87 | NPC1 (0.53) | HDAC6HDAC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4249831 | 0.81 | KMT2A (0.52) | HDAC6NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4251239 | 0.80 | POLB (0.49) | HDAC6HDAC1NPC1ALOX15RAB9A | |
| SCHEMBL4257493 | 0.80 | ALDH1A1 (0.60) | NPC1ALOX15RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3978755 | 0.80 | HTR1A (0.62) | HDAC6HDAC1NPC1PLK1BCAT1 | |
| SCHEMBL4257390 | 0.79 | NPC1 (0.71) | HDAC6HDAC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4252991 | 0.79 | KMT2A (0.56) | HDAC6HDAC1NPC1HTTRAB9A | |
| SCHEMBL13736544 | 0.79 | ADRA1A (0.53) | HDAC6HDAC1NPC1PLK1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | HDAC6 11/4885HDAC1 1/4885NPC1 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.