Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | UGT1A4 | P22310 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 5/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947573 | 0.84 | ALDH1A1 (0.56) | LMNAALDH1A1MAPTKDM4EGAA | |
| SCHEMBL545449 | 0.80 | LMNA (0.53) | LMNAALDH1A1MAPTKDM4EGAA | |
| SCHEMBL29777509 | 0.80 | LMNA (0.53) | LMNAALDH1A1MAPTKDM4EGAA | |
| SCHEMBL3933818 | 0.80 | ALDH1A1 (0.46) | LMNAALDH1A1MAPTKDM4EGAA | |
| SCHEMBL22712682 | 0.79 | LMNA (0.67) | LMNAALDH1A1MAPTKDM4EGAA | |
| SCHEMBL4243942 | 0.79 | ALDH1A1 (0.42) | LMNAALDH1A1MAPTKDM4EGAA | |
| SCHEMBL3934249 | 0.77 | CHKA (0.48) | ALDH1A1MAPTKDM4EGAATSHR | |
| SCHEMBL21416852 | 0.74 | LMNA (0.42) | LMNAALDH1A1MAPTKDM4EGAA | |
| SCHEMBL18775271 | 0.73 | LMNA (0.59) | LMNAALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL15000246 | 0.72 | LMNA (0.57) | LMNAALDH1A1MAPTKDM4EMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279759-A | 3- ((8- ((1H-pyrazol-4-yl) amino) imidazo [1,2-a ] pyridin-3-yl) ethynyl) -N-phenylbenzamide derivative, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient | 大邱庆北尖端医疗产业振兴财团 | 2022-11-01 | — | — | CN | disclosed |
| US-20090170849-A1 | QUINAZOLINONE DERIVATIVES HAVING B-RAF INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | US | disclosed |
| CN-101415688-A | Quinazolone derivative with B-RAF inhibition activity | ASTRAZENECA AB (SE) | 2009-04-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170849-A1 | QUINAZOLINONE DERIVATIVES HAVING B-RAF INHIBITORY ACTIVITY | BRAF, ARAF, RAF1 | LMNA 2340/4885ALDH1A1 468/4885MAPT 4520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.