Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | ATP4A | P20648 | 2/20 | 0.49 |
| ▸ | ATP4B | P51164 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933463 | 0.82 | RAB9A (0.51) | GSK3BCYP19A1ATP4AATP4BAURKA | |
| SCHEMBL11895098 | 0.80 | GSK3B (0.62) | GSK3BCYP19A1ATP4AATP4BAURKA | |
| SCHEMBL17422799 | 0.76 | CDK5 (0.57) | GSK3BCYP19A1ATP4AATP4BAURKA | |
| SCHEMBL31626826 | 0.75 | CYP19A1 (0.59) | GSK3BCYP19A1ATP4AATP4BAURKA | |
| SCHEMBL701368 | 0.75 | CYP19A1 (0.59) | GSK3BCYP19A1ATP4AATP4BAURKA | |
| SCHEMBL17422726 | 0.75 | CDK5 (0.56) | GSK3BCYP19A1ATP4AATP4BAURKA | |
| SCHEMBL4247549 | 0.74 | CYP19A1 (0.62) | GSK3BCYP19A1AURKAAURKBNPC1 | |
| SCHEMBL25168239 | 0.74 | CYP19A1 (0.72) | GSK3BCYP19A1AURKAAURKBNPC1 | |
| SCHEMBL23641151 | 0.73 | GSK3B (0.62) | GSK3BCYP19A1ATP4AATP4BAURKA | |
| SCHEMBL9828516 | 0.73 | AURKA (0.55) | GSK3BCYP19A1ATP4AATP4BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB (publ) (SE) | 2009-04-08 | — | — | EP | claimed |
| WO-2007147874-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB (PUBL) (SE) | 2007-12-27 | — | — | WO | claimed |