Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | ITK | Q08881 | 3/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31626826 | 1.00 | CYP19A1 (0.59) | CYP19A1GSK3BMETAP2AURKAAURKB | |
| SCHEMBL20852020 | 0.84 | CYP19A1 (0.61) | CYP19A1GSK3BMETAP2AURKAAURKB | |
| SCHEMBL18993607 | 0.84 | CYP19A1 (0.48) | CYP19A1GSK3BMETAP2ITKCDK5 | |
| SCHEMBL29470995 | 0.81 | GSK3B (0.61) | CYP19A1GSK3BMETAP2AURKAAURKB | |
| SCHEMBL308319 | 0.81 | GSK3B (0.61) | CYP19A1GSK3BMETAP2AURKAAURKB | |
| SCHEMBL4278217 | 0.80 | METAP2 (0.40) | CYP19A1GSK3BMETAP2CCNB2CDK1 | |
| SCHEMBL18443452 | 0.79 | PIM1 (0.67) | ITKPIM1 | |
| SCHEMBL18445724 | 0.78 | ITK (0.65) | CYP19A1AURKAAURKBITKMAP2K1 | |
| SCHEMBL20451132 | 0.78 | ITK (0.60) | ITKCHEK1PIM1 | |
| SCHEMBL5179280 | 0.77 | ITK (0.61) | CYP19A1GSK3BAURKAAURKBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3788116-A1 | CHEMILUMINESCENT IMIDAZOPYRAZINONE-BASED PHOTOSENSITIZERS WITH AVAILABLE SINGLET AND TRIPLET EXCITED STATES | Universidade do Porto (PT) | 2021-03-10 | — | — | EP | claimed |
| US-8124789-B2 | Method for producing glycosylated indole compound and antibody against the compound | RIKEN (JP) | 2012-02-28 | — | — | US | claimed |
| US-20100028329-A1 | METHOD FOR PRODUCING GLYCOSYLATED INDOLE COMPOUND AND ANTIBODY AGAINST THE COMPOUND | RIKEN (JP) | 2010-02-04 | — | — | US | claimed |
| EP-3788116-B1 | CHEMILUMINESCENT IMIDAZOPYRAZINONE-BASED PHOTOSENSITIZERS WITH AVAILABLE SINGLET AND TRIPLET EXCITED STATES | UNIV DO PORTO (PT) | 2022-09-07 | — | — | EP | disclosed |
| EP-3788116-A1 | CHEMILUMINESCENT IMIDAZOPYRAZINONE-BASED PHOTOSENSITIZERS WITH AVAILABLE SINGLET AND TRIPLET EXCITED STATES | Universidade do Porto (PT) | 2021-03-10 | — | — | EP | disclosed |
| EP-2569286-B1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMA (US) | 2014-08-20 | — | — | EP | disclosed |
| US-8124789-B2 | Method for producing glycosylated indole compound and antibody against the compound | RIKEN (JP) | 2012-02-28 | — | — | US | disclosed |
| US-8124789-B2 | Method for producing glycosylated indole compound and antibody against the compound | RIKEN (JP) | 2012-02-28 | — | — | US | disclosed |
| US-20100048596-A2 | Indole Derivatives as Antitumoral Compounds | PHARMA MAR, S.A. (ES) | 2010-02-25 | — | — | US | disclosed |
| US-20100028329-A1 | METHOD FOR PRODUCING GLYCOSYLATED INDOLE COMPOUND AND ANTIBODY AGAINST THE COMPOUND | RIKEN (JP) | 2010-02-04 | — | — | US | disclosed |
| US-20100028329-A1 | METHOD FOR PRODUCING GLYCOSYLATED INDOLE COMPOUND AND ANTIBODY AGAINST THE COMPOUND | RIKEN (JP) | 2010-02-04 | — | — | US | disclosed |
| JP-2009137885-A | METHOD FOR PRODUCING GLYCOSYLATED INDOLE COMPOUND | INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH | 2009-06-25 | — | — | JP | disclosed |
| US-20090124647-A1 | Indole Derivatives as Antitumoral Compounds | PHARMA MAR, S.A. (ES) | 2009-05-14 | — | — | US | disclosed |
| EP-1951711-A1 | INDOLE DERIVATIVES AS ANTITUMOURAL COMPOUNDS | Pharma Mar, S.A. (ES) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007054748-A1 | INDOLE DERIVATIVES AS ANTITUMOURAL COMPOUNDS | PHARMA MAR, S.A. (ES) | 2007-05-18 | — | — | WO | disclosed |
| CN-1320037-A | Antiviral indoloxoacetylpiperazine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2001-10-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124647-A1 | Indole Derivatives as Antitumoral Compounds | NPR3, IDO1, ADORA3 | CYP19A1 1510/4885GSK3B 1366/4885METAP2 3921/4885 |
| US-20100048596-A2 | Indole Derivatives as Antitumoral Compounds | NPR3, IDO1, ADORA3 | CYP19A1 1510/4885GSK3B 1366/4885METAP2 3921/4885 |
| US-20100028329-A1 | METHOD FOR PRODUCING GLYCOSYLATED INDOLE COMPOUND AND ANTIBODY AGAINST THE COMPOUND | TPH1, IDO1, TPH2 | CYP19A1 639/4885GSK3B 267/4885METAP2 1555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.