Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PYGL | P06737 | 7/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.34 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296724 | 0.94 | ALDH1A1 (0.47) | ALDH1A1PYGLPKMSIGMAR1KMT2A | |
| SCHEMBL25676926 | 0.82 | PYGL (0.31) | ALDH1A1PYGL | |
| SCHEMBL30925974 | 0.77 | — | — | |
| SCHEMBL14712982 | 0.75 | — | — | |
| SCHEMBL8294310 | 0.74 | ALDH1A1 (0.45) | ALDH1A1PYGLPKMSIGMAR1KMT2A | |
| SCHEMBL3562816 | 0.73 | — | — | |
| SCHEMBL226831 | 0.73 | — | — | |
| SCHEMBL4156333 | 0.73 | — | — | |
| SCHEMBL8294307 | 0.72 | ALDH1A1 (0.44) | ALDH1A1PYGLPKMSIGMAR1KMT2A | |
| SCHEMBL13059399 | 0.71 | ALDH1A1 (0.42) | ALDH1A1PKMSIGMAR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077719-A2 | PIPERIDINE AND PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck and Co., Inc. (US) | 2009-07-15 | — | — | EP | claimed |
| WO-2008036316-A2 | PIPERIDINE AND PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2008-03-27 | — | — | WO | claimed |
| EP-3319963-B1 | SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-01-08 | — | — | EP | disclosed |