SCHEMBL4249060

SCHEMBL4249060

CC(C)(C)OC(=O)c1cc(=O)c2cccc(N)c2o1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 11/20 0.42
MAOB P27338 2/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
KDM4E B2RXH2 2/20 0.39
ATM Q13315 1/20 0.38
USP2 O75604 1/20 0.38
CSNK2A2 P19784 1/20 0.38
PTGS1 P23219 1/20 0.38
CSNK2B P67870 1/20 0.38
CSNK2A1 P68400 1/20 0.38
CSNK2A3 Q8NEV1 1/20 0.38
AKR1B1 P15121 2/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4251645 0.85 KDM4E (0.53) GPR35MAOBGAAMAPTKDM4E
SCHEMBL4247291 0.83 AKR1B1 (0.56) GPR35MAOBGAAMAPTKDM4E
SCHEMBL4254725 0.82 AKR1B1 (0.57) GPR35MAOBGAAMAPTKDM4E
SCHEMBL4248824 0.81 ESR1 (0.47) GPR35MAOBGAAMAPTKDM4E
SCHEMBL29394263 0.81 MAPT (0.63) MAOBGAAMAPTKDM4EATM
SCHEMBL4250503 0.80 GPR35 (0.67) GPR35MAOBGAAMAPTKMT2A
SCHEMBL4250588 0.80 MAOB (0.69) GPR35MAOBMAPTKDM4EATM
SCHEMBL4252013 0.80 MAOB (0.49) GPR35MAOBGAAMAPTKDM4E
SCHEMBL4253451 0.79 GPR35 (0.61) GPR35KDM4EUSP2CSNK2A2PTGS1
SCHEMBL28290283 0.79 GPR35 (0.47) GPR35KDM4EUSP2CSNK2A2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101497571-B Process for producing chromone compound SUMITOMO CO LTD 2012-07-04 CN disclosed
CN-1911896-B Process for producing benzopyrone compound SUMITOMO CHEMICAL CO 2010-09-15 CN disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
CN-101497571-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2009-08-05 CN disclosed
CN-100509751-C Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2009-07-08 CN disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
CN-1911896-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2007-02-14 CN disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
CN-1649824-A Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2005-08-03 CN disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL GPR35 2693/4885MAOB 476/4885GAA 2812/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL GPR35 2693/4885MAOB 476/4885GAA 2812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.