SCHEMBL4254725

SCHEMBL4254725

CCOC(=O)c1cc(=O)c2cccc(N)c2o1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.57
MAOB P27338 2/20 0.56
SLC2A1 P11166 1/20 0.49
ATM Q13315 1/20 0.48
TP53 P04637 1/20 0.47
THRB P10828 1/20 0.47
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
RAB9A P51151 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HSD17B10 Q99714 2/20 0.46
MAPT P10636 2/20 0.46
KDM4E B2RXH2 2/20 0.46
NPC1 O15118 1/20 0.46
HPGD P15428 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
GPR35 Q9HC97 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MAPK1 P28482 1/20 0.46
GAA P10253 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4250588 0.90 MAOB (0.69) AKR1B1MAOBATMKMT2AMEN1
SCHEMBL4252681 0.89 MAOB (0.60) AKR1B1MAOBSLC2A1ATMTP53
SCHEMBL22617428 0.88 MAOB (0.61) AKR1B1MAOBSLC2A1ATMTP53
SCHEMBL4247253 0.88 MAOB (0.59) AKR1B1MAOBATMTP53KMT2A
SCHEMBL4252013 0.87 MAOB (0.49) AKR1B1MAOBATMKMT2AMEN1
SCHEMBL4256564 0.87 MAOB (0.58) AKR1B1MAOBATMTP53KMT2A
SCHEMBL8106509 0.86 AKR1B1 (0.56) AKR1B1MAOBSLC2A1ATMTP53
SCHEMBL8827768 0.85 AKR1B1 (0.55) AKR1B1MAOBSLC2A1ATMTP53
SCHEMBL7633152 0.85 AKR1B1 (0.59) AKR1B1MAOBSLC2A1ATMTP53
SCHEMBL4251645 0.85 KDM4E (0.53) MAOBATMKMT2AALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101497571-B Process for producing chromone compound SUMITOMO CO LTD 2012-07-04 CN disclosed
CN-1911896-B Process for producing benzopyrone compound SUMITOMO CHEMICAL CO 2010-09-15 CN disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
CN-101497571-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2009-08-05 CN disclosed
CN-100509751-C Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2009-07-08 CN disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
CN-1911896-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2007-02-14 CN disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed
US-5459134-A Leukotriene antagonists; phospholipase, 5-alpha-reductase, and aldose reductase inhibitors ONO PHARMACEUTICAL CO., LTD. (JP) 1995-10-17 US disclosed
US-5446058-A Leukotriene antagonists, 5-alpha-reductase inhibitors ONO PHARMACEUTICAL CO., LTD. (JP) 1995-08-29 US disclosed
EP-0463638-B1 Aminophenyl derivatives ONO PHARMACEUTICAL CO (JP) 1995-05-24 EP disclosed
EP-0173516-B1 (Fused)benz(thio)amides ONO PHARMACEUTICAL CO (JP) 1993-12-01 EP disclosed
US-4939141-A (Fused) benz (thio) amides and pharmaceutical compositions, thereof ONO PHARMACEUTICAL CO., LTD. (JP) 1990-07-03 US disclosed
US-4847275-A ENZYME INHIBITOR, LEUKOTRIENE ANTAGONIST ONO PHARMACEUTICAL CO., LTD. (JP) 1989-07-11 US disclosed
US-4780469-A (Fused) benz(thio)amides and pharmaceutical use ONO PHARMACEUTICAL CO., LTD. (JP) 1988-10-25 US disclosed
EP-0173516-A2 (Fused)benz(thio)amides ONO PHARMACEUTICAL CO., LTD. (JP) 1986-03-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL AKR1B1 237/4885MAOB 476/4885SLC2A1 2436/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL AKR1B1 237/4885MAOB 476/4885SLC2A1 2436/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.