SCHEMBL4251645

SCHEMBL4251645

COC(=O)c1cc(=O)c2cccc(N)c2o1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.53
GPR35 Q9HC97 10/20 0.48
MAPT P10636 2/20 0.45
GAA P10253 1/20 0.45
MAOB P27338 1/20 0.45
LMNA P02545 1/20 0.43
ATM Q13315 1/20 0.43
KMT2A Q03164 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.42
ALDH1A1 P00352 1/20 0.41
CFTR P13569 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4247291 0.86 AKR1B1 (0.56) KDM4EGPR35MAPTGAAMAOB
SCHEMBL4249060 0.85 GPR35 (0.42) KDM4EGPR35MAPTGAAMAOB
SCHEMBL4254725 0.85 AKR1B1 (0.57) KDM4EGPR35MAPTGAAMAOB
SCHEMBL8115765 0.83 ALDH1A1 (0.57) KDM4EGPR35MAPTGAALMNA
SCHEMBL8119628 0.83 KDM4E (0.50) KDM4EGPR35MAPTGAAMAOB
SCHEMBL4250588 0.83 MAOB (0.69) KDM4EGPR35MAPTMAOBATM
SCHEMBL4252013 0.83 MAOB (0.49) KDM4EGPR35MAPTGAAMAOB
SCHEMBL4253451 0.82 GPR35 (0.61) KDM4EGPR35ALDH1A1
SCHEMBL28290283 0.82 GPR35 (0.47) KDM4EGPR35LMNAKMT2AALDH1A1
SCHEMBL4252681 0.82 MAOB (0.60) KDM4EGPR35MAPTGAAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101497571-B Process for producing chromone compound SUMITOMO CO LTD 2012-07-04 CN disclosed
CN-1911896-B Process for producing benzopyrone compound SUMITOMO CHEMICAL CO 2010-09-15 CN disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
CN-101497571-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2009-08-05 CN disclosed
CN-100509751-C Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2009-07-08 CN disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
CN-1911896-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2007-02-14 CN disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
CN-1649824-A Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2005-08-03 CN disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL KDM4E 978/4885GPR35 2693/4885MAPT 4765/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL KDM4E 978/4885GPR35 2693/4885MAPT 4765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.