SCHEMBL4249090

SCHEMBL4249090

Nc1ccccc1C(=O)Oc1ccc(Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 9/20 0.61
ALDH1A1 P00352 9/20 0.61
HPGD P15428 6/20 0.61
KDM4E B2RXH2 5/20 0.61
GLA P06280 2/20 0.61
CFTR P13569 1/20 0.53
CYP1A2 P05177 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
ATM Q13315 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
ALOX15 P16050 1/20 0.47
SMN1; SMN2 Q16637 5/20 0.46
RAB9A P51151 4/20 0.46
NPC1 O15118 3/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9861291 0.91 HSD17B10 (0.71) HSD17B10ALDH1A1HPGDKDM4EGLA
SCHEMBL9394319 0.87 HPGD (0.55) HSD17B10ALDH1A1HPGDKDM4ECYP1A2
SCHEMBL6430896 0.86 ALDH1A1 (0.65) HSD17B10ALDH1A1HPGDKDM4EGLA
SCHEMBL28785606 0.85 HPGD (0.53) HSD17B10ALDH1A1HPGDKDM4ECYP1A2
SCHEMBL444509 0.85 HSD17B10 (0.64) HSD17B10ALDH1A1HPGDKDM4EGLA
SCHEMBL28030331 0.84 ALDH1A1 (0.59) HSD17B10ALDH1A1HPGDKDM4EGLA
SCHEMBL25063269 0.83 HSD17B10 (0.61) HSD17B10ALDH1A1HPGDKDM4EGLA
SCHEMBL4256427 0.83 ALDH1A1 (0.61) HSD17B10ALDH1A1HPGDKDM4EGLA
SCHEMBL25063288 0.83 HSD17B10 (0.61) HSD17B10ALDH1A1HPGDKDM4EGLA
SCHEMBL4246573 0.83 ALDH1A1 (0.66) HSD17B10ALDH1A1HPGDKDM4EGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 US disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 US disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 US disclosed
US-20090131527-A1 NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2009-05-21 US disclosed
EP-0138761-B1 PROCESS FOR THE PIGMENTATION OF MACROMOLECULAR ORGANIC MATERIALS CIBA-GEIGY AG (CH) 1989-03-22 EP disclosed
US-4602961-A MONOAZO BENZOTHIAZOLE DERIVATIVES CIBA-GEIGY CORPORATION (US) 1986-07-29 US disclosed
EP-0138761-A2 Process for the pigmentation of macromolecular organic materials CIBA-GEIGY AG (CH) 1985-04-24 EP disclosed
US-4224025-A Process for the dyeing and printing of paper materials in different hues using a single coupling component CIBA-GEIGY CORPORATION (US) 1980-09-23 US disclosed
US-4168952-A ACETOACETIC ACID ARYLAMIDE AS COUPLER HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1979-09-25 US disclosed
US-4165967-A HYDROXY-PYRIDINE OR PYRIDONE COUPLERS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1979-08-28 US disclosed
US-4162893-A Process for dyeing human hair with diazo salts HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1979-07-31 US disclosed
US-4065254-A DIAZO DYES, LEATHER, COTTON, WOOL CIBA-GEIGY CORPORATION (US) 1977-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131527-A1 NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME CLIC1, ASIC1, CLIC4 HSD17B10 1998/4885ALDH1A1 1179/4885HPGD 2548/4885
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 HSD17B10 2241/4885ALDH1A1 1427/4885HPGD 3064/4885
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 HSD17B10 2241/4885ALDH1A1 1427/4885HPGD 3064/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.