Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.88 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | CES1 | P23141 | 2/20 | 0.63 |
| ▸ | CA1 | P00915 | 3/20 | 0.61 |
| ▸ | CA2 | P00918 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28148545 | 0.94 | SRD5A2 (0.89) | SRD5A2TDP1MAPK1POLBLMNA | |
| 4-Nitrobenzoic Acid SCHEMBL43476 | 0.94 | TDP1 (1.00) | SRD5A2TDP1MAPK1POLBLMNA | |
| Terephthalic Acid SCHEMBL28023943 | 0.94 | TDP1 (1.00) | SRD5A2TDP1MAPK1POLBLMNA | |
| 4-Nitrobenzoic Acid SCHEMBL1566327 | 0.91 | TDP1 (0.95) | SRD5A2TDP1MAPK1POLBLMNA | |
| 4-Nitrobenzoic Acid SCHEMBL7553997 | 0.91 | TDP1 (0.95) | SRD5A2TDP1MAPK1POLBLMNA | |
| 4-Nitrobenzoic Acid SCHEMBL10439552 | 0.91 | TDP1 (0.95) | SRD5A2TDP1MAPK1POLBLMNA | |
| 4-Nitrobenzoic Acid SCHEMBL3860571 | 0.91 | TDP1 (0.95) | SRD5A2TDP1MAPK1POLBLMNA | |
| 4-Nitrobenzoic Acid SCHEMBL17332086 | 0.91 | TDP1 (0.95) | SRD5A2TDP1MAPK1POLBLMNA | |
| 4-Nitrobenzoic Acid SCHEMBL11331124 | 0.91 | TDP1 (0.95) | SRD5A2TDP1MAPK1POLBLMNA | |
| 4-Nitrobenzoic Acid SCHEMBL17332065 | 0.91 | TDP1 (0.95) | SRD5A2TDP1MAPK1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105294622-B | A kind of isoandrographolide class compound and preparation method and application | 华南理工大学 | 2017-06-06 | — | — | CN | disclosed |
| CN-105294622-A | Isoandrographolide compound, preparing method thereof and application thereof | UNIV SOUTH CHINA TECH | 2016-02-03 | — | — | CN | disclosed |
| US-7491735-B2 | Chemokine receptor binding compounds | GENZYME CORPORATION (US) | 2009-02-17 | — | — | US | disclosed |
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| US-20050277670-A1 | Chemokine receptor binding compounds | ANORMED INC. | 2005-12-15 | — | — | US | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |
| US-5464912-A | Adduct with rodlike mesogenic moiety, adduct made by reacting polyepoxide with nitro/so/ compound having epoxy-reactive hydrogen; conversion of hydroxyl product to ether, ester, halide, urethane, ketone, alkane; reducing nitro/so/ to amine | THE DOW CHEMICAL COMPANY (US) | 1995-11-07 | — | — | US | disclosed |
| US-5412044-A | Nitro group terminated mesogenic epoxy resin adducts | THE DOW CHEMICAL COMPANY (US) | 1995-05-02 | — | — | US | disclosed |
| US-5344898-A | Curable composition with stilbene groups and molecular orientation | THE DOW CHEMICAL COMPANY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5298575-A | Consists of at least one compound having more than one vicinal epoxide group and at least one amine terminated adduct containing one or more mesogenic moities | THE DOW CHEMICAL COMPANY (US) | 1994-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277670-A1 | Chemokine receptor binding compounds | CCR5, CXCR3, CCL5 | SRD5A2 2236/4885TDP1 4502/4885MAPK1 1005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.