SCHEMBL4249693

SCHEMBL4249693

C#CCOc1ccc(C(=O)NCC2CCC2)cc1F

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.46
HDAC6 Q9UBN7 2/20 0.44
MLYCD O95822 1/20 0.44
BCHE P06276 2/20 0.44
MAOB P27338 2/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
MAPK14 Q16539 3/20 0.43
TDP1 Q9NUW8 1/20 0.43
MMP13 P45452 1/20 0.42
NAMPT P43490 1/20 0.41
CA2 P00918 1/20 0.41
POLB P06746 1/20 0.41
CYP2C9 P11712 1/20 0.41
MCHR1 Q99705 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4248441 0.98 HDAC6 (0.47) ARHDAC6MLYCDBCHEMAOB
SCHEMBL4253070 0.97 HDAC6 (0.49) ARHDAC6MLYCDBCHEMAOB
SCHEMBL4247076 0.95 AR (0.49) ARHDAC6BCHEMAOBMAPK14
SCHEMBL4241637 0.89 LDLR (0.42) MEN1KMT2AMAPK14NAMPT
SCHEMBL4247585 0.87 LDLR (0.44) MEN1KMT2AMAPK14
SCHEMBL4242220 0.85 TDP1 (0.56) MEN1KMT2AMAPK14TDP1POLB
SCHEMBL4249949 0.85 TDP1 (0.48) ARHDAC6MLYCDBCHEMAOB
SCHEMBL4252805 0.84 ROCK2 (0.42) ARMEN1KMT2AMAPK14NAMPT
SCHEMBL4244608 0.83 TDP1 (0.59) MEN1KMT2AMAPK14TDP1MMP13
SCHEMBL4252787 0.82 TDP1 (0.51) HDAC6MLYCDMEN1KMT2AMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902400-B2 N-(1,1-diemthylpropyl)-4-(2-propynyloxy)-3-methoxybenzamide; N-(2,2-diemthylpropyl)-4-(2-propynyloxy)-3-methoxybenzamide; controlling plant diseases SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-03-08 US disclosed
US-7902400-B2 N-(1,1-diemthylpropyl)-4-(2-propynyloxy)-3-methoxybenzamide; N-(2,2-diemthylpropyl)-4-(2-propynyloxy)-3-methoxybenzamide; controlling plant diseases SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-03-08 US disclosed
US-7902400-B2 N-(1,1-diemthylpropyl)-4-(2-propynyloxy)-3-methoxybenzamide; N-(2,2-diemthylpropyl)-4-(2-propynyloxy)-3-methoxybenzamide; controlling plant diseases SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-03-08 US disclosed
US-20090131531-A1 Amide Compounds and their Use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-05-21 US disclosed
US-20090131531-A1 Amide Compounds and their Use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-05-21 US disclosed
US-20090131531-A1 Amide Compounds and their Use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-05-21 US disclosed
EP-1940780-A1 AMIDE COMPOUNDS AND THEIR USE SUMITOMO CHEMICAL CO., LTD. (JP) 2008-07-09 EP disclosed
WO-2007049728-A1 AMIDE COMPOUNDS AND THEIR USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-05-03 WO disclosed
WO-2007049728-A1 AMIDE COMPOUNDS AND THEIR USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-05-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131531-A1 Amide Compounds and their Use NAT1, ACAT2, NAAA AR 4202/4885HDAC6 239/4885MLYCD 181/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.