Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250070 | 1.00 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2PTGDR2RORC | |
| SCHEMBL4256619 | 0.92 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2PTGDR2RORC | |
| SCHEMBL4256626 | 0.92 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2PTGDR2RORC | |
| SCHEMBL3189536 | 0.88 | RORC (0.42) | NPC1RAB9ASMN1; SMN2PTGDR2RORC | |
| SCHEMBL3206229 | 0.88 | RORC (0.42) | NPC1RAB9ASMN1; SMN2PTGDR2RORC | |
| SCHEMBL4252553 | 0.87 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL4253076 | 0.83 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL3196559 | 0.80 | RORC (0.42) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL3205533 | 0.80 | RORC (0.42) | NPC1RAB9ASMN1; SMN2RORCDHODH | |
| SCHEMBL3206541 | 0.80 | RORC (0.42) | NPC1RAB9ASMN1; SMN2RORCDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090192168-A1 | Compounds, Compositions and Methods | CYTOKINETICS, INCORPORATED | 2009-07-30 | — | — | US | claimed |
| US-20090192168-A1 | Compounds, Compositions and Methods | CYTOKINETICS, INCORPORATED | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192168-A1 | Compounds, Compositions and Methods | TNNI3, TNNC1, TNNT2 | NPC1 4637/4885RAB9A 2875/4885SMN1; SMN2 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.